Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Device and method for preparing pulsatile release microspheres

A pulsed release and microsphere technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problem that the microspheres cannot exhibit pulsed drug release behavior, and achieve strong controllability of the release behavior, low energy consumption, and drug release. High stability effect

Inactive Publication Date: 2014-11-05
ZHEJIANG PHARMA COLLEGE
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, microspheres prepared by existing preparation techniques such as emulsified solvent diffusion method, emerging membrane emulsification technology, and microfluidic technology cannot yet exhibit pulsed drug release behavior.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Device and method for preparing pulsatile release microspheres
  • Device and method for preparing pulsatile release microspheres
  • Device and method for preparing pulsatile release microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1, the preparation device of pulse release microspheres figure 1 As shown, it includes: a constant flow pump 1, a constant flow pump 2, a constant flow pump 3, a coaxial nozzle 4, a frequency generator 5, a signal amplifier 6, an ultrasonic transducer 7, a collection container 8 and a stirrer 9. The coaxial nozzle 4 is a concentric three-port nozzle, in which the inner diameter of the inner nozzle is 100 μm And connected to the constant flow pump 1 through an independent liquid delivery pipeline, the inner diameter of the middle nozzle is 200 μm It is connected to the constant flow pump 2 through an independent liquid delivery pipeline, and the inner diameter of the outer nozzle is 400 μm It is connected to the constant flow pump 3 through an independent liquid delivery pipeline. A collection container 8 with a stirrer 9 is placed under the coaxial nozzle 4. The ultrasonic transducer 7 is connected to the coaxial nozzle 4, and the ultrasonic transducer 7 The syste...

Embodiment 2

[0034] Example 2. The preparation device of pulse release microspheres is as figure 1 As shown, it includes: a constant flow pump 1, a constant flow pump 2, a constant flow pump 3, a coaxial nozzle 4, a frequency generator 5, a signal amplifier 6, an ultrasonic transducer 7, a collection container 8 and a stirrer 9. The coaxial nozzle 4 is a concentric three-port nozzle, in which the inner diameter of the inner nozzle is 100 μm And connected to the constant flow pump 1 through an independent liquid delivery pipeline, the inner diameter of the middle nozzle is 200 μm It is connected to the constant flow pump 2 through an independent liquid delivery pipeline, and the inner diameter of the outer nozzle is 400 μm It is connected to the constant flow pump 3 through an independent liquid delivery pipeline. A collection container 8 with a stirrer 9 is placed under the coaxial nozzle 4. The ultrasonic transducer 7 is connected to the coaxial nozzle 4, and the ultrasonic transducer 7 The...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a device and a method for preparing pulsatile release microspheres. The device comprises three constant-flow pumps, coaxial nozzles, a frequency generator, a signal amplifier, an ultrasonic transducer, a collection container and a stirrer. The coaxial nozzles are three homocentric nozzles comprising an inner nozzle, a middle nozzle and an outer nozzle. The inner nozzle, the middle nozzle and the outer nozzle are connected respectively to the three constant-flow pumps by independent liquid delivery pipes and respectively convey a drug solution, a polymer solution and a stabilizing solution. The method comprises that through adjustment of flowing rates of the constant-flow pumps, jet flows produced by the coaxial nozzles; the ultrasonic transducer vibrates and resonates with the coaxial nozzles so that the jet flows are broken into uniform micro-droplets; the micro-droplets drop in the collection container with the stirrer; and particles prepared by the previous step are polymer solution-coated drugs and contact with the stabilizing solution so that a polymer is precipitated and is solidified into core-shell microspheres. Microsphere drug release is controlled by properties of a polymer and after a polymer shell is degraded, a drug is released intensively in a pulse way.

Description

Technical field [0001] The invention relates to a preparation technology of pulsed microspheres, in particular to a device and method for preparing microspheres by means of acoustic wave excitation atomization technology. Background technique [0002] In recent years, the long-acting and sustained-release formulations of protein and peptide drugs have become a research focus. After such drugs are injected into the human body, if the drugs can be released regularly and quantitatively according to physiological and therapeutic needs, it will be more beneficial to the efficacy of the drugs. Such as hormones and other drugs that release in the body with a clear circadian rhythm, have a wide range of first-pass effects, interact with receptors for long-term stimulation to inactivate them to produce drug-resistant drugs, and vaccines that require multiple vaccination, pulsed administration More ideally, the pulse vaccine can be used for vaccination to replace the current common multip...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04
Inventor 胡英钦富华
Owner ZHEJIANG PHARMA COLLEGE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com