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Production method of fructose diphosphate sodium sterile powder

A kind of technology of sodium fructose diphosphate and production method, which is applied in the direction of preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of lack of sterility, product quality decline, high equipment cost, etc., and achieve the goal of reducing contact Opportunity, aseptic quality assurance, and the effect of reducing labor intensity

Active Publication Date: 2012-12-26
张家港市华天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, ordinary activated carbon filters are generally used for sterilization and filtration. Activated carbon filters can only remove impurities with relatively large particles in the solution, and the sterilization effect is not good.
In addition, limited by the existing drying machine (only with drying function), the solid-liquid separation step and drying step can only be operated step by step and divided into equipment, which has high labor intensity, low production efficiency, high equipment cost, and energy consumption. Large and the product is easy to deteriorate due to exposure to air and the outside world or the introduction of impurities, etc., which cannot meet the requirements of sterility

Method used

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  • Production method of fructose diphosphate sodium sterile powder
  • Production method of fructose diphosphate sodium sterile powder
  • Production method of fructose diphosphate sodium sterile powder

Examples

Experimental program
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Effect test

Embodiment 1

[0031] This embodiment provides a vacuum rotary dryer used in the method of the present invention. Such as Figure 1 to Figure 4 As shown, the vacuum rotary dryer includes a frame 1; a tank body 2 with an inlet and an outlet 20, the tank body 2 can be rotatably arranged on the frame 1, and its axis of rotation is consistent with the horizontal direction; A variable frequency motor 3 used to drive the tank body 2 to rotate; a vacuum device 4 connected to the tank body 2; a drying device for drying materials in the tank body 2; wherein the vacuum device 4 includes a vacuum tube that extends into the tank body 2 at one end 40. Vacuum pump; a filter screen 5 arranged in the tank body 2 for solid-liquid separation, a filtrate container 6 located below the filter screen 5, a filtrate discharge pipe 7 communicating with the filtrate container 6 for discharging the filtrate therein, A vacuum filter 8 arranged at the filtrate outlet of the filtrate container 6 .

[0032] In the dryin...

Embodiment 2

[0035] This embodiment provides a sterilizing filter device used in the method of the present invention. Such as Figure 5 with Image 6 As shown, the sterilizing and filtering device includes a fixed seat 15, two feed pipes 16 respectively arranged on the upper parts of both sides of the fixed seat 15, two discharge pipes 17 respectively arranged on the lower parts of the fixed seats 15 both sides, and two outlet pipes 17 arranged on each side. Five sets of ultrafiltration membrane modules 18 between the feed pipe 16 and the discharge pipe 17. There is a one-to-one correspondence between the five sets of ultrafiltration membrane modules 18 on both sides, and the upper and lower parts of the corresponding two ultrafiltration membrane modules 18 are communicated by connecting pipes 19 . The upper and lower ends of the central pipe 180 of the ultrafiltration membrane module 18 communicate with the feed pipe 16 and the discharge pipe 17 respectively. The structure of the ultra...

Embodiment 3

[0037] The present embodiment provides a kind of production method of sodium fructose diphosphate aseptic powder, specifically as follows:

[0038] Put 350kg of fructose diphosphate sodium bacteria powder raw material into a 1000L dissolving tank, add 300L of water for injection, heat the jacket, control the jacket temperature to 45°C, and filter it with a carbon rod after it is completely dissolved, and pass the filtrate through a 0.22 micron filter in turn After sterilizing and filtering with the sterilizing and filtering device described in embodiment 2, enter the intermediate storage tank, afterward, with the aseptic compressed air through sterilizing, the filtrate is pressed into the crystallization tank, and sterile alcohol (volume ratio 92% ) 780L. By adjusting the temperature of the water in the jacket of the crystallization tank, the temperature of the feed liquid is controlled at 28-30°C. After the temperature is stable, add 300g of qualified sodium fructose diphospha...

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Abstract

The invention relates to a production method of fructose diphosphate sodium sterile powder. The production method comprises the following steps of: dissolving fructose diphosphate sodium non-sterile powder with injection water, and then filtering by using carbon rods; filtering sequentially through a filter with bore diameters of 0.2-0.4 micrometer and a sterilization and filter device; then pressing sterilized compressed air into a crystallizing tank, and adding sterilized alcohol by controlling the liquid temperature to be 28-30 DEG C; adding a qualified fructose diphosphate sodium sterile raw drug as seed crystal to crystallize; after crystallization is finished, compressing a solid-liquid mixture into a vacuum rotary type drier by using sterile air to sequentially separate, wash and dry; and then oscillated screening, weighing, inside packaging and outside packaging to obtain the fructose diphosphate sodium sterile powder. The production method has the advantages of simple operation, lower cost and good quality of the fructose diphosphate sodium sterile powder.

Description

technical field [0001] The invention relates to a production method of sodium fructose diphosphate aseptic powder. Background technique [0002] Sodium fructose diphosphate, molecular formula: C 6 h 11 o 12 P 2 Na 3 ·8H 2 O, the chemical structural formula is as follows: [0003] [0004] Sodium fructose diphosphate is a white or off-white crystalline powder with a slight peculiar smell and mild taste. It is easily soluble in water and almost insoluble in ether, ethanol or acetone. [0005] Sodium fructose diphosphate is a cell metabolite present in the human body, which can regulate the activity of various enzyme systems in glucose metabolism. According to reports, exogenous sodium fructose diphosphate can increase the concentration of adenosine triphosphate and creatine phosphate in cells by activating the activity of phosphofructokinase and pyruvate kinase, and promote the influx of potassium ions, which is beneficial to ischemia and hypoxia. Cell energy metabo...

Claims

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Application Information

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IPC IPC(8): C07H11/04C07H1/06
Inventor 徐继嗣张彪
Owner 张家港市华天药业有限公司
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