Hypovolemic shock treatment nasal administration preparations of valproic acid and salts thereof

A technology for nasal administration preparations and low blood volume, which is applied in the field of chemical pharmaceuticals, and can solve the problems of slow onset of action and difficulty in shock patients

Inactive Publication Date: 2012-12-26
王晓青 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the main dosage forms of valproic acid are oral tablets and injections. The onset of oral administration is slow, and it is not easy for shock patients. Injection is the most effective way. Under the conditions of on-site treatment of hypovolemic shock, injection administration is difficult to implement, which limits the application of valproic acid as an emergency drug
At present, the anti-shock research of valproic acid is only found in the report of subcutaneous injection in animals

Method used

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  • Hypovolemic shock treatment nasal administration preparations of valproic acid and salts thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] Preparation method: Dissolve 0.5g of sodium carboxymethylcellulose, 0.1g of ethylparaben, and 5.0g of sodium chloride in 100ml of water for later use, weigh 200.0g of sodium valproate fine powder dried to constant weight, and place in 100ml In the volumetric flask, add 90ml of the above solution, shake to dissolve completely, add the solution to the full amount, filter to obtain sodium valproate solution.

Embodiment 2

[0025] The comparison of blood drug concentration in beagle dogs after nasal cavity administration of solution of the present invention and sodium valproate solution intravenous administration.

[0026] Prepare the sodium valproate nasal spray containing 800mg according to embodiment 1, prepare the sodium valproate sterilized aqueous solution containing 800mg in addition. Eight Beagle dogs were divided into two groups, one group was given the above-mentioned nasal spray, and the other group was intravenously given sterilized aqueous solution of sodium valproate. See Table 1 for the plasma concentrations of Beagle dogs at different time points.

[0027] Table 1 Comparison of blood drug concentration after intranasal administration of sodium valproate spray and intravenous administration of sodium valproate solution in Beagle dogs (n=4)

[0028]

[0029] The blood drug concentration peaked 30 minutes after administration of the above-mentioned nasal spray, and maintained a g...

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Abstract

The present invention relates to nasal administration preparations of valproic acid and salts thereof, wherein the preparations are suitable for hypovolemic shocks caused by war wound (wound), burn, and the like. The preparation of the present invention contains a prototype drug of valproic acid, or a pharmaceutically acceptable salt, an ester, an amide or di-sodium valproate of the valproic acid, and a pharmaceutically effective auxiliary material, wherein the prototype drug of valproic acid, or the pharmaceutically acceptable salt, the ester, the amide or the di-sodium valproate of the valproic acid is adopted as a main component.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a preparation for nasal administration of valproic acid and its salt. After administration, valproic acid and its salt can be quickly absorbed into the blood to achieve effective blood drug concentration and intracerebral drug concentration. While improving the survival rate, it also has a protective effect on important organs such as the brain and heart, and has become an effective drug for the treatment of hypovolemic shock. Background technique [0002] Hypovolemic shock is a common complication after war, trauma and extensive burns. It can cause tissue cell metabolism disorder and vital organ function damage. If not treated in time, the wounded will die in a short time. Whether the shock period passes smoothly is crucial to the subsequent course and outcome of the disease. [0003] The most effective way to treat hypovolemic shock is timely and adequate fluid th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/10A61K9/14A61K9/16A61K9/00A61K31/19A61P7/08
Inventor 王晓青胡森刘霏
Owner 王晓青
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