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Application of arctigenin in treating angiogenesis diseases

An arctigenin and generative technology is applied in the field of medicine to achieve the effects of reducing the occurrence of complications, widening medication indications and improving medication compliance.

Inactive Publication Date: 2012-12-05
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Arctigenin has significant antibacterial, antiviral, antitumor, and anti-PAF receptor effects, but whether it has the effect of inhibiting angiogenesis has not been seen in literature and clinical reports. The inventors have found that arctigenin has Significantly inhibits the effect of angiogenesis, thus proposing the application of arctigenin in the treatment of drugs for the treatment of angiogenesis diseases

Method used

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  • Application of arctigenin in treating angiogenesis diseases
  • Application of arctigenin in treating angiogenesis diseases
  • Application of arctigenin in treating angiogenesis diseases

Examples

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Effect test

Embodiment 1

[0019] The preparation of embodiment 1 tablet

[0020]

[0021] Preparation process: mix arctigenin, auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are passed through a 20-mesh sieve for granulation, the fine powder in the dry granules is screened out, mixed with magnesium stearate, and then mixed with the dry granules, pressed into tablets, each tablet is about 200mg, that is, .

Embodiment 2

[0022] The preparation of embodiment 2 injection

[0023] Arctigenin 10g

[0024] Tween 80 1g

[0025] Water for injection 1000mL

[0026] Preparation process: Mix 10g arctigenin and 1g Tween evenly, add 1000mL of water for injection, and divide into packages.

Embodiment 3

[0027] The preparation of embodiment 3 capsules

[0028] Arctigenin 100g

[0029] Lactose 120g

[0030] Cornstarch 130g

[0031] Magnesium Stearate 5g

[0032] Preparation process: 100g of arctigenin, 120g of lactose and 130g of corn starch are mixed in a mixer for 10-15 minutes, 5g of magnesium stearate is added and mixed for 1-3 minutes, and then filled into 1000 capsule shells.

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Abstract

The invention provides a novel medical application of arctigenin, belonging to the field of medicine. According to the application of arctigenin in treating angiogenesis diseases provided by the invention, the arctigenin is applied to treating angiogenesis diseases, a good angiogenesis inhibiting effect is shown in a chorioallantoic membrane model test of a chicken embryo, which reminds that the arctigenin can be applied to treatment or auxiliary treatment of angiogenetic diseases. The medical application of arctigenin which inhibits angiogenesis reminds that the arctigenin has wide medical application prospect in treating diseases such as tumor and other pathological angiogenesis diseases such as diabetic retinopathy, psoriasis, atherosclerosis, rheumatoid arthritis and the like.

Description

technical field [0001] The invention belongs to the new technology of medicine and relates to a new medical application of arctigenin, in particular to the application of arctigenin in preparing medicine for treating angiogenesis diseases, and belongs to the field of medicine. Background technique [0002] Angiogenesis is the process by which capillaries sprout from former vessels to form new vascular beds. Most of the blood vessels in the body maintain a high degree of stability after they are fully developed, and their angiogenesis is slow and difficult to detect. However, under physiological and pathological conditions such as trauma repair, periodic endometrium, and some diseases, active angiogenesis occurs. In tumors, rheumatism, psoriasis and other disease states, uncontrolled angiogenesis is the key to the occurrence and development of diseases. These diseases can be called "angiogenic diseases" or "angiogenic diseases". Angiogenesis is a necessary condition for tumo...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P35/00A61P35/04A61P3/10A61P9/10A61P17/06A61P19/02
Inventor 赵志全刘奋王洪臣
Owner LUNAN PHARMA GROUP CORPORATION
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