Methods and compositions for hydrophobic modification of oral cavity surfaces

A compositional, hydrophobic technology for the treatment and modification of teeth and other oral surfaces to address issues such as diminished long-term efficacy

Inactive Publication Date: 2012-11-28
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While oral hygiene products are generally useful for cleaning and protecting the oral cavity from these factors, the short-term exposure of the active substance and its rapid clearance from the oral cavity minimizes the longer-term efficacy of the active substance contained in the oral hygiene product

Method used

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  • Methods and compositions for hydrophobic modification of oral cavity surfaces
  • Methods and compositions for hydrophobic modification of oral cavity surfaces
  • Methods and compositions for hydrophobic modification of oral cavity surfaces

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0211] Embodiment 1: Toothpowder composition

[0212] Dentifrice compositions I-A-I-G according to the present invention and comparative examples I-H (without organophosphates) are shown below, ingredients are in % by weight. These compositions are prepared by conventional methods.

[0213]

Embodiment II

[0214] Example II: Multiphase Oral Care Products

[0215] The following illustrates a stable oral care product comprising two or more different compositions each contained in physically separate compartments such as a dentifrice dispenser. Each product comprises at least a first composition (II-A1-II-A4) and at least a second composition (II-B1-II-B6), said first composition comprising one or more selected surface active An organophosphate compound, said second composition comprising incompatible actives such as stannous, zinc and calcium cations. Formulating negatively charged organophosphates and cations together in a single composition can cause precipitation which renders both the cation and the organophosphate compound inactive and impairs their intended beneficial effects. Formulating these incompatible ingredients in separate phases allows optimal delivery of cationic and organophosphate agents to the oral cavity.

[0216] Element

II-A1

II-A2

I...

Embodiment III

[0219] Example III. Oral Care Compositions

[0220] A comparative example (III-B) of an oral care composition comprising an organophosphate salt according to the invention and a non-abrasive gel form is shown below, ingredients in % by weight. These compositions are prepared by conventional methods and can be used, for example, as polishing or sealing gels to prevent active substances already deposited on surfaces from being washed off quickly.

[0221] Element

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PUM

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Abstract

Oral care compositions containing agents that are effective for treating and modifying teeth and mucosal surfaces to be hydrophobic are disclosed. Hydrophobic modification of teeth and other oral cavity surfaces imparts a variety of end use benefits including prevention of caries, erosion, wear, staining, sensitivity and desquamation as well as providing shine, smoothness and positive tooth feel benefits. The compositions contain selected surface active organophosphate compounds that deposit and adhere to teeth and other oral cavity surfaces forming a hydrophobic coating having prolonged retention thereon. By forming a "hydrophobic coating" on the oral cavity surface is meant that the hydrophobic character of the surface is increased as measured, for example, by an increase of at least about 10 degrees in the water contact angle of the surface after treatment. The increased hydrophobic character of the surface is maintained for a period of at least about 5 minutes and desirably longer such as at least about 10, at least about 20 or at least about 30 minutes. The compositions may contain additional hydrophobic materials to further increase hydrophobicity of the surface and / or functionality of the coating to provide surface protection and many other benefits.

Description

technical field [0001] Compositions comprising selected surface-active organophosphate compounds and the use of these compositions for treating and modifying teeth and other oral surfaces are provided. When applied to oral surfaces, the compositions of the present invention form a substantially hydrophobic coating of one or more surface-active organophosphate compounds on the treated surface. Organophosphate compounds are deposited on tooth and mucosal surfaces via linkages or bonds formed between the phosphate groups of the compounds and cationic sites on the target surface. The treated surface has increased hydrophobicity, which in turn imparts a variety of end-use benefits to the surface, including ease of cleaning; enhanced retention of actives, such as fluoride, on teeth; and surface protection benefits, especially improved tooth resistance. Bacterial or biofilm adhesion, aggressive demineralization or dissolution, resistance to sensitivity and staining, and protection f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q11/00
CPCA61Q11/02A61K8/55A61Q11/00A61K8/24A61K8/556
Inventor 阿里夫·阿里·拜格贾扬塔·拉贾亚乔治·恩德尔·德克纳威廉·迈克尔·格兰多夫
Owner THE PROCTER & GAMBLE COMPANY
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