Methods and compositions for diagnosis and prognosis of renal injury and renal failure
A technology for acute renal failure and renal status, which can be used in disease diagnosis, biological testing, biomaterial analysis, etc., and can solve problems such as delayed diagnosis of AKI
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Embodiment 1
[1142] Example 1: Sample collection of contrast agent-induced nephropathy
[1143] The purpose of this sample collection study was to collect plasma and urine samples and clinical data from patients before and after receiving intravascular contrast media. Approximately 250 adults undergoing radiographic / angiographic procedures involving intravascular administration of iodinated contrast media were recruited. In order to enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:
[1144] Inclusion criteria
[1145] Men and women aged 18 or over;
[1146] Undergoing a radiographic / angiographic procedure involving intravascular administration of contrast media (eg, CT scan or coronary intervention);
[1147] Hospitalization is expected for at least 48 hours after contrast administration.
[1148] Able and willing to provide written consent to participate in the study and follow all study procedures. ...
Embodiment 2
[1159] Example 2: Sample Collection for Cardiac Surgery
[1160] The purpose of this sample collection study was to collect plasma and urine samples and clinical data from patients before and after undergoing cardiovascular surgery, a procedure known to be potentially hazardous to renal function. Approximately 900 adults undergoing this procedure were recruited. To enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:
[1161] Inclusion criteria
[1162] Men and women aged 18 or over;
[1163] undergone cardiovascular surgery;
[1164] The Toronto / Ottawa Predictive Risk Index for Renal Replacement Risk Score is at least 2 (Wijeysundera et al., JAMA 297:1801-9, 2007); and
[1165] Able and willing to provide written consent to participate in the study and follow all study procedures.
[1166] exclusion criteria
[1167] known pregnancy;
[1168] previous kidney transplant;
[1169] Acute d...
Embodiment 3
[1173] Example 3: Sample collection from acutely ill patients
[1174] The purpose of this study was to collect samples from acutely ill patients. Approximately 900 adults expected to spend at least 48 hours in the ICU will be recruited. To enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:
[1175] Inclusion criteria
[1176] Men and women aged 18 or over;
[1177] Study Population 1: Approximately 300 patients with at least one of the following:
[1178] Shock (SBP 60mmHg and / or documented SBP drop of at least 40mmHg); and
[1179] sepsis;
[1180] Study Population 2: Approximately 300 patients with at least one of the following:
[1181] Administer IV antibiotics per Computerized Physician Order Entry (CPOE) within 24 hours of enrollment;
[1182] Exposure to contrast media within 24 hours of enrollment;
[1183] Increased intra-abdominal pressure with acute decompensated heart fail...
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