Methods for diagnosis and treatment of non-insulin dependent diabetes mellitus

A technology for type 2 diabetes and polymorphism, applied in chemical instruments and methods, biochemical equipment and methods, metabolic diseases, etc.

Inactive Publication Date: 2012-11-14
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] But even without developing hyperglycemia and diabetes, the health of these insulin-resistant individuals comes at a great cost

Method used

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  • Methods for diagnosis and treatment of non-insulin dependent diabetes mellitus
  • Methods for diagnosis and treatment of non-insulin dependent diabetes mellitus
  • Methods for diagnosis and treatment of non-insulin dependent diabetes mellitus

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Embodiment 1

[0152] Establishment of genome-wide microarray experiment database for type 2 diabetes (T2D). A T2D genome-wide functional experiment database was created by collecting and reanalysing all publicly available T2D-related microarray studies (69 experiments, totaling 518 microarrays) at the time of the study. Microarray experiments included multiple tissue types (muscle, liver, fat, and islets) and species (human, mouse, and rat). Each of the 20994 genes in the database was counted and sorted based on the number of microarray experiments in which each gene was significantly dysregulated from 69 microarray study groups.

[0153] All 69 publicly available data from T2D-related genome-wide microarray experiments were collected from three sources (Table 2). First, raw quantitative data of microarrays were selected and downloaded from Gene Expression Omnibus (GEO) by keyword searching for "diabetes" or "diabetics" or "NIDDM" or "non-insulin-dependent". Experiments involving type 1 d...

Embodiment 2

[0180] Example 2 Integration of publicly available microarray experiments found that CD44 is genetically and functionally involved in type 2 diabetes.

[0181] Type 2 diabetes (T2D) is a complex multifactorial disease phenotypically characterized by insulin resistance. Accumulating evidence suggests a causal link between low-grade inflammation (macrophage infiltration) in adipose tissue and the development of insulin resistance / T2D. To find causative T2D-associated genes, we performed a meta-analysis of 518 publicly available T2D-associated microarrays, based on our hypothesis that differentially expressed genes in the T2D crossover model are strong candidates for functional variants. We extracted our best data-driven candidate, the immune receptor CD44, and demonstrated a strong association of the coding variant with T2D in 2830 T2D cases and 1928 controls from two independent cohorts (rs1071695; OR =1.43[1.17-1.74], P=3.9×10 -4 ). We also extracted OPN, a ligand encoding ...

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Abstract

Methods and compositions are provided for the treatment and diagnosis of diseases related to hyperglycemic conditions, including diabetes, insulin resistance, and the like. Genetic polymorphisms are shown to be associated with disease susceptibility, and their detection is used in the diagnosis of a predisposition to these conditions. The corresponding proteins are useful as targets for therapeutic intervention.

Description

[0001] Statement of Government Support [0002] This invention was made with US Government support under funding from the National Institutes of Health. The government has certain rights in this invention. Background technique [0003] Diabetes is a metabolic disease that occurs when the pancreas does not produce enough of the hormone insulin to regulate blood sugar ("type 1 diabetes"), or when the body cannot effectively use the insulin it produces ("type 2 diabetes"). [0004] According to recent estimates by the World Health Organization, more than 200 million people worldwide have diabetes, 90 percent of whom have type 2 diabetes. Typical long-term complications include the development of neuropathy, retinopathy, nephropathy, general degenerative changes of large or small blood vessels, and increased susceptibility to infection. Since individuals with type 2 diabetes also have residual amounts of insulin available relative to individuals with type 1 diabetes who are comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/10A61K31/7088A61K39/395
CPCC07K14/70585C12Q2600/156C12Q1/6883A61P3/10
Inventor 阿图尔·J.·布特児玉桂一
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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