Application of medicament composition in preparing drug for preventing or treating senile dementia

A composition and senile technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve problems such as complex components

Active Publication Date: 2012-11-14
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the traditional Chinese medicines used to treat senile dementia are large prescriptions with complex components such as CN101269174A, CN101229293A, CN1266707A, CN1181966A, CN1478498A, etc. Therefore, it is very important to find traditional Chinese medicine prescriptions with simple components and definite curative effects

Method used

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  • Application of medicament composition in preparing drug for preventing or treating senile dementia
  • Application of medicament composition in preparing drug for preventing or treating senile dementia
  • Application of medicament composition in preparing drug for preventing or treating senile dementia

Examples

Experimental program
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Effect test

Embodiment 1

[0010] The following examples are further explanations of the present invention, and cannot be used as further limitations on the protection scope of the present invention. The drug effect evaluation of embodiment 1 pharmaceutical composition to scopolamine hydrobromide-induced learning and memory impairment model in mice

[0011] The qualified healthy KM mice were randomly divided into 8 groups, namely normal group, model group, and huperzine A group (dose 0.07mg / kg, batch number: 090503, specification: 0.3mg / tablet, Henan Tailong Pharmaceutical Co., Ltd. Co., Ltd.), Acanthopanax extract group (300mg / kg, prepared according to the method of Example 8), Hypericum perforatum extract group (prepared according to the method of Example 9 for dose 300mg / kg), pharmaceutical composition A (prepared by the method of Example 9 for dose 300mg / kg, prepared by the method of Example 3), pharmaceutical composition B (the dosage is 300mg / kg, prepared by the method of Example 4), pharmaceutic...

Embodiment 2

[0016] Example 2 The drug effect evaluation of the pharmaceutical composition on the APPswe transgenic senile dementia mouse model

Embodiment 9

[0017] Take 5-month-old APPswe transgenic mice (from Nanjing Institute of Animal Modeling, the mice express human presenilin and human mouse amyloid preprotein, leading to senile dementia), male and female are divided into 8 groups randomly, that is, the model Group, Huperzine A group (dose 0.067mg / kg, batch number: 090503, specification: 0.3mg / tablet, Henan Tailong Pharmaceutical Co., Ltd.), Acanthopanax extract group (300mg / kg, according to Example 8 method to prepare), Hypericum perforatum extract group (300mg / kg, prepared by the method of Example 9), pharmaceutical composition A (prepared by the method of Example 3) low-dose group (120mg / kg), middle-dose group (240mg / kg) kg), high-dose group (480mg / kg), APPswe mice with the same background and the same month age (from Nanjing Institute of Animal Modeling, the mice did not express human presenilin and human mouse amyloid precursor protein, and did not cause senile dementia ) is the normal group, 10 rats in each group. Each...

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Abstract

The invention provides application of a medicament composition in preparing a medicament for preventing or treating senile dementia, wherein the medicament composition is prepared by processing herba hyperici perforate and acanthopanax root, and adding auxiliary materials acceptable pharmaceutically into various dosage forms. The pharmacological research shows that the composition plays the certain role of preventing and treating senile dementia, and obviously improves the learning disabilities and memory ability.

Description

technical field [0001] The invention relates to the field of medical applications, in particular to the application of a pharmaceutical composition in the preparation of medicines for preventing or treating senile dementia. Background technique [0002] With the continuous acceleration of the pace of the world's entry into the aging society, various neurodegenerative senile diseases, such as mild cognitive impairment and Alzheimer's disease, have become important risk factors that threaten the health of human beings in their later years and reduce the quality of life of the elderly. The society and family have brought serious economic burden and heavy mental pressure. Alzheimer's disease can be divided into Alzheimer's disease (AD) and vascular dementia as well as mixed dementia. Nervous dysfunction is clinically manifested as deteriorating cognition and memory function, progressive decline in daily life ability, and various neuropsychiatric symptoms and behavioral disorder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P25/28
Inventor 柯尊洪高小平
Owner SICHUAN JISHENGTANG PHARMLS
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