Multi-cell mechanical simulation experiment platform

Abstract

The invention provides a multi-cell mechanical loading device. The loading device comprises a piston of which the upper end is provided with a brace and a loading box of which one side is provided with an opening, wherein the specification of the piston is consistent with the internal specification of the loading box; the bottom of the loading box is provided with a sensor; and a signal acquisition instrument is arranged outside the loading box. The invention also provides a multi-cell mechanical simulation experiment platform. The experiment platform comprises the multi-cell mechanical loading device as mentioned above, a computer system and a universal material testing machine with a clamp, wherein the multi-cell mechanical loading device is fixed on the clamp; and the computer system is connected with the universal material testing machine. The invention has the following advantages: through the up-and-down movement of the piston, air is compressed to load pressure to cells, the stress uniformity of the cells can be ensured, and the accuracy of the determination result can be improved; the movement of the piston is controlled by the universal material testing machine, the pressure loading process can be exactly simulated, rapid response is achieved, and a complicated pressure change process can be simulated; and the multi-cell mechanical simulation experiment platform has the advantages of simple structure and convenience in operation.

Description

technical field [0001] The invention relates to the technical field of cell biomechanics, in particular to a multi-cell mechanical simulation experiment platform. Background technique [0002] Cell biomechanics (mechanocytobiology) is the frontier of the current development of life sciences, involving many aspects of cell mechanics research, one of the hotspots is the damage of cells caused by mechanical force, and the impact of related mechanical effects on cell growth, reorganization, mechanical Signal transduction and gene expression as well as the effects of processes such as ATP synthesis. The in-depth study of cell biomechanics has not only played an important role in promoting the current research on cell and tissue engineering, molecular biomechanics and bioengineering, biomechanics of various soft and hard tissues, biomechanical models and biomaterials, but also has important implications for life. The further development and breakthrough of science will exert imme...

AI Technical Summary

Problems solved by technology

This device can quantitatively control the magnitude of the applied compressive stress, the frequency of action and the duration of action, etc., but the device has the following defects: (1) The cell culture chamber and the cylinder are connected through a vent tube, and the gas finally enters the cell culture through the vent tube Diffusion behind the chamber, and the diffusion movement of the gas has both forward diffusion and diffusion to the surroundings, which leads to uneven force on the cells in the cell culture chamber, and errors in the simulation experiment results; (2) Need Multi-stage decompression devices, solenoid valves, etc. are used to control the gas frequency and air pressure. The response time of the components is long, and the sensitivity is poor. It is difficult to simulate the more complex mechanical loading process, such as the inventor Ding Jifeng. The scientific curve shows: the amplitude of the vertical wave of the Jigong method is high, the ascending branch is steep, the rising angle is large, and the wave crest is sharp. , due to the complexity of the mechanical loading process and the large pressure gap between adjacent processes, it will be difficult to accurately simulate using the above-mentioned device

In summary, there is an urgent need for a device that can accurately simulate complex mechanical loading processes and uniform pressure loading, but there are no reports on such devices

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