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Preparation process and matrix for gel cream for treating coronary heart disease

A technology of matrix and gel, applied in the field of preparation process and matrix formulation of the drug, can solve the problems of insufficient viscosity, long production cycle, poor stability and the like

Inactive Publication Date: 2012-10-31
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, traditional Chinese medicine gel ointment also generally has the disadvantages of insufficient viscosity, poor stability, and long production cycle. Therefore, the present invention provides a kind of "internal disease external treatment" plaster variety that can be administered locally and act on the whole body.

Method used

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  • Preparation process and matrix for gel cream for treating coronary heart disease
  • Preparation process and matrix for gel cream for treating coronary heart disease

Examples

Experimental program
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Effect test

Embodiment

[0041] Prepare coronary heart extract according to the following process:

[0042] 1. Soak Dalbergia basil in 6 times of water for 2 hours, then extract the volatile oil by steam distillation for 8 hours, collect the volatile oil, filtrate and medicinal residues and store them in another container;

[0043] 2. Extract Danshen, Ligusticum Chuanxiong, and Dalbergia dregs together with 5 times the amount of 90% ethanol three times, each time for 0.5h, and recover the ethanol to a relative density of 1.15-1.25 (measured at 50°C);

[0044] 3. Radix Paeoniae Rubra together with the above dregs, extract 3 times with 10 times the amount of water, 0.5 hours each time, add safflower soaked in 10 times the water for 30 minutes at the last extraction, filter, and concentrate to 0.2g The medicinal liquid with crude drug / ml concentration is purified by macroporous adsorption resin: the process conditions are: the ratio of diameter to height is 1:7, the sample solution is 8 times the amount of...

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PUM

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Abstract

The invention discloses gel cream for treating a coronary heart disease and a preparation process and a matrix accessory formula for the gel cream for treating the coronary heart disease. Salvia miltiorrhiza, radix paeoniae rubra, rhizoma chuanxiong, safflower carthamus and dalbergia wood in a prescription are extracted and refined to obtain an extract, and the extract and a proper matrix are prepared into the gel cream, the gel cream is used for treating thoracic obstruction, chest stuffiness and precordial pain which are caused by internal blockage of static blood and cardiovascular diseases such as angina pectoris with the above symptoms. The preparation method comprises extracting essential oil from the dalbergia wood by a water vapor distilling method; extracting the salvia miltiorrhiza, the rhizoma chuanxiong and dregs of the dalvergia wood by 90% of ethanol, and extracting the dregs of the salvia miltiorrhiza, the rhizoma chuanxiong and the dalvergia wood, the radix paeoniae rubra and the safflower carthamus by water; purifying filtrate by macroreticular resin; concentrating the purified liquid medicine into liquid medicine with the relative density of 1.15-1.25 (measured at the temperature of 50 DEG C ), combining the liquid medicine with an ethanol extracted cream, mixing the mixture with the matrix and finally adding the essential oil; and stirring for 20-120 minutes, and coating, pressing and cutting to obtain the refined gel cream for treating the coronary heart disease. Eluent is equal to 40% of ethanol and is four times of the resin, and the elution speed is 3BV / H.

Description

technical field [0001] The present invention relates to a transdermal external dosage form for the treatment of thoracic obstruction caused by internal stagnation of blood stasis, symptoms such as chest tightness and precordial pain: coronary heart disease, angina pectoris, and cardiovascular diseases with the above-mentioned symptoms - refined coronary heart disease Tablets converted into a gel ointment. The invention particularly relates to the preparation process and matrix formulation of the medicine. Background technique [0002] The traditional Chinese medicine prescription of the present invention is derived from the first volume of the Pharmacopoeia of the People's Republic of China 2010 edition, and the original dosage form is a tablet. Refined Guanxin Tablets are mainly used clinically for the treatment and prevention of coronary heart disease. According to the theory of "internal disease external treatment" in traditional Chinese medicine, the present invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/70A61K9/00A61K47/42A61K47/38A61P9/10
Inventor 刘淑芝梁日欣李曼玲杜茂波王岚吴志成康琛王彦礼
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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