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Isinglass empty capsule

A hollow capsule and fish gelatin technology, which is applied in directions such as capsule transportation, can solve the problems of multifunctionality, cannot provide gelatin, and is not as convenient as gelatin for processing, and achieves the effect of increasing drug efficacy and increasing use.

Active Publication Date: 2012-10-31
青岛益青生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as starch, chemically modified starch, carrageenan, xanthan gum and carob gum, however these products do not provide as many functions as gelatin, unlike gelatin which has a high protein content, polysaccharide gums have setting strength but require additives, and Not heat reconstitutable and thus not as easy to process as gelatin

Method used

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  • Isinglass empty capsule
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 60 parts of fish gelatin (freezing power value 240), add 2 parts of carrageenan, 0.8 parts of potassium chloride, 0.05 parts of sodium lauryl sulfate, and 0.10 parts of polyethylene glycol, stir the above materials evenly, and add them to 200 parts of 85 Stir in purified water above ℃ for 1-2 hours, until all dissolve evenly, and stabilize at 60℃ for more than 2 hours. Fish gelatin hollow capsules can be produced on a fully automatic capsule machine.

Embodiment 2

[0026] Take 65 parts of fish gelatin (freezing power value 180), add 0.1 part of gellan gum, 0.2 part of potassium citrate, 0.05 part of sodium lauryl sulfate, and 0.10 part of polyethylene glycol, stir the above materials evenly, and add to 250 Parts of purified water above 85°C, stirred for 1-2 hours, until all dissolved evenly, stable at 60°C for more than 2 hours. Fish gelatin hollow capsules can be produced on a fully automatic capsule machine.

Embodiment 3

[0028] Take 62 parts of fish gelatin (freezing power value 200), add 1.0 part of carrageenan, 1.0 part of locust bean gum, 0.2 part of potassium citrate, 0.05 part of sodium lauryl sulfate, and 0.10 part of polyethylene glycol, and stir the above materials Evenly, add it to 250 parts of purified water above 85°C, stir for 1-2 hours, until it is completely dissolved and stable at 60°C for more than 2 hours. Fish gelatin hollow capsules can be produced on a fully automatic capsule machine.

[0029] The produced fish gelatin empty capsules meet the standard requirements of the 2010 edition of the Pharmacopoeia:

[0030]

[0031]

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Abstract

The invention provides an isinglass empty capsule, aiming to meet the requirements for drug intake of special crowds and to adapt to the development need of the market. The isinglass empty capsule adopts the technical scheme that the isinglass empty capsule comprises the following components in percentage by weight: 82.5-87.5% of isinglass, 0.1-2.0% of gelata, 0.04-0.4% of gelatin additive, 0.05-0.25% of plasticizer, 0.001-0.02% of release agent, 0.00-0.002% of coloring agent, and the balance of water. The isinglass empty capsule is the potential need of gelatin market as well as the need forproviding high-quality gelatin empty capsules, and can increase the usage of isinglass at the same time.

Description

technical field [0001] The invention relates to the field of medical capsules, in particular to a fish gelatin hollow capsule. Background technique [0002] At present, hollow capsules are mainly made of gelatin extracted from bovine bone or pigskin, and gelatin has good properties when preparing capsules. However, in recent years, due to the spread of various infectious diseases such as mad cow disease and foot-and-mouth disease carried by cattle, pigs and other animals, many countries have reduced or banned the production and use of gelatin and food derived from cattle and pigs. and imports; on the other hand, due to religious beliefs, Muslim consumers reject and refuse to use gelatin and food products produced from pig skin or beef bones. Therefore, new gelatin resources must be developed and tapped. [0003] Likewise, the pharmaceutical industry is actively looking for alternatives to mammalian gelatin, and the European Pharmacopoeia states that pharmaceutical manufact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 刘秀彦杨涌
Owner 青岛益青生物科技股份有限公司
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