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Application of patchouli oil in preparation of medicines used for treating colpitis

A technology of Huoxiang oil and vaginitis, which is applied in the field of medicine and health, can solve the problems of drug resistance and large side effects, and achieve the effect of definite curative effect and good clinical application prospect

Active Publication Date: 2012-10-24
CHENGDU HUASUN GRP INC LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, most of the commonly used drugs for the treatment of vaginitis are antibiotics and broad-spectrum antibacterial drugs, with large side effects and widespread use will lead to drug resistance

Method used

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  • Application of patchouli oil in preparation of medicines used for treating colpitis
  • Application of patchouli oil in preparation of medicines used for treating colpitis
  • Application of patchouli oil in preparation of medicines used for treating colpitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Huoxiang oil of the present invention

[0024] Take the whole herb of Pogostemon cablin (Blanco) Benth., crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak it for 1-5 hours, and extract it by steam distillation for 2-6 hours, that is Get the Huoxiang oil of the present invention, wherein contain bokuli alcohol (C 15 h 26 O) shall not be lower than 26.0%.

Embodiment 2

[0025] The preparation of embodiment 2 Huoxiang oil of the present invention

[0026] Take the whole herb of Agastache rugosa (Fisch.Et Mey.) O.Ktze., crush it through a 20-40 mesh sieve, add 10-14 times the weight of distilled water, soak for 1-5 hours, and extract 2 by steam distillation. -6 hours, to obtain Huoxiang oil of the present invention.

[0027] Huoxiang oil of the present invention also can extract according to Pharmacopoeia (2005 edition) appendix XD volatile oil determination method, also can adopt organic solvent extraction, supercritical CO 2 extraction and other existing techniques, or obtain by purchasing commercially available products.

[0028] Prove the beneficial effects of the present invention below by drug efficacy test:

experiment example 1

[0029] Experimental Example 1 The activity of Huoxiang oil of the present invention in the treatment of candida vaginitis

[0030] 1. Materials and instruments

[0031]1.1 Experimental strains

[0032] ① Standard strain: Candida albicans standard strain (ATCC14053), from American Clinical Laboratory Culture Collection Center; Candida albicans standard strain (CICC32819) and Candida albicans standard strain (CICC31284), purchased from China Industrial Microbiology Culture Collection Management center.

[0033] ②Clinical isolates: 14 strains of Candida albicans, which were isolated from the vaginal secretions of patients in the gynecology clinic of Sichuan Provincial Maternal and Child Health Hospital from September to December 2011, and identified by KC-16 of BIO-KONT Company and drug sensitivity The disk was identified as Candida albicans.

[0034] 1.2 Drugs

[0035] Test drug: Huoxiang oil of the present invention (prepared according to the method of Example 1).

[0036]...

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PUM

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Abstract

The invention discloses application of patchouli oil in preparation of medicines used for treating colpitis. The invention also discloses a pharmaceutical composition which is a medicament prepared from the active component of patchouli oil and pharmaceutically acceptable adjuvants or adjuvant components. Patchouli oil has a substantial curative effect on colpitis and has a strong practical application value.

Description

technical field [0001] The invention relates to a new application of Huoxiang oil, which belongs to the field of medicine and health. Background technique [0002] Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, and is a common disease in gynecological clinics. For normal healthy women, due to anatomical and biochemical characteristics, the vagina has a natural defense function against the invasion of pathogens. When the natural defense function of the vagina is destroyed, pathogens are easy to invade and cause vaginal inflammation. At present, the treatment of vaginitis is mainly based on anti-infection and anti-inflammation, supplemented by physical therapy. The commonly used treatment methods include medicinal vaginal douching, local drug delivery, and oral medication. Common vaginitis includes bacterial vaginosis, candida vaginitis, trichomonas vaginitis, and senile vaginitis. [0003] Bacterial vaginosis is a mixed infection caused...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61P15/02A61P31/04A61P33/02
Inventor 彭成代敏王蓬勃林大胜王天祥彭颖
Owner CHENGDU HUASUN GRP INC LTD
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