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Solid dispersion of frankincense extract and preparation method thereof

A technology of solid dispersion and extract, applied in the field of solid dispersion of frankincense extract and preparation thereof, can solve problems such as incomplete utilization of frankincense extract, and achieve the advantages of improving bioavailability, wide application range and simple and feasible process. Effect

Inactive Publication Date: 2012-09-26
SHANDONG QIDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to improve the dissolution of frankincense extract, the method of adding surfactant is generally adopted, but this method cannot fundamentally solve the problem of incomplete utilization of frankincense extract

Method used

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  • Solid dispersion of frankincense extract and preparation method thereof
  • Solid dispersion of frankincense extract and preparation method thereof
  • Solid dispersion of frankincense extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of Boswellia total triterpenes solid dispersion with polyethylene glycol 6000 (PEG6000) as carrier:

[0033] This example investigates the preparation of total triterpenoid extract of frankincense and PEG6000 dispersion carrier with different mass ratios. Mix Boswellia extract and PEG6000 at the ratio of 50:1, 30:1, 20:1, 10:1, 5:1, 1:1, 1:5, 1:10, 1:30, dissolve in ethanol solution middle, stirring, mixing evenly, rotary evaporating, distilling off the ethanol solution, cooling, drying in a vacuum drier, pulverizing, grinding, passing through a 40-mesh sieve to obtain the total triterpenoid dispersion of frankincense. Carry out blank experiment simultaneously, detect the dissolution rate of frankincense total triterpenoids in 0.3% SDS dilute hydrochloric acid solution, 0.3% SDS aqueous solution by the method described in the instructions, the results are shown in Table 1.

[0034] Table 1 Dissolution of frankincense total triterpenes PEG6000 dispersion

...

Embodiment 2

[0038] Different methods to prepare frankincense total triterpenes PEG6000 solid dispersion:

[0039] This example examines different preparation methods to prepare frankincense total triterpenes PEG6000 solid dispersion. The total triterpenoid extract of Boswellia and PEG6000 are mixed according to the mass ratio of 5:1, and the solid of Boswellia total triterpenoid extract PEG6000 is prepared according to different preparation methods such as grinding method, ultrafine powder method, spray drying method, melting method, solvent method, etc. Dispersions. Carry out blank experiment simultaneously, detect the dissolution rate of frankincense total triterpenoids in 0.3% SDS dilute hydrochloric acid solution, 0.3% SDS aqueous solution by the method described in the instructions, the results are shown in Table 2.

[0040] Table 2 Different methods prepare the dissolution rate of frankincense total triterpenes PEG6000 solid dispersion

[0041]

[0042] This example illustrates...

Embodiment 3

[0044] Preparation of Boswellia total triterpenes solid dispersion of different types of PEG as carrier:

[0045] This example examines the preparation of solid dispersions of total triterpenoids of frankincense with different PEG carrier materials. Boswellia extract containing 50% of the total triterpenoids of Boswellia by mass ratio is mixed with PEG4000, PEG6000, PEG12000, PEG20000, PEG6000-PEG12000 mixture (mass ratio 1:1), dissolved in ethanol solution, Stir, mix evenly, rotary evaporate, distill off the ethanol solution, cool, dry in a vacuum drier, pulverize, grind, and pass through a 100-mesh sieve to obtain the solid dispersion of frankincense total triterpenoids. Carry out blank experiment simultaneously, detect the dissolution rate of frankincense total triterpenoids in 0.3% SDS dilute hydrochloric acid solution, 0.3% SDS aqueous solution by the method described in the instructions, the results are shown in Table 3.

[0046] Table 3 The dissolution rate of the tota...

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Abstract

The invention relates to a solid dispersion of frankincense extract and a preparation method thereof, belonging to the field of pharmaceutical intermediates and preparation thereof. The solid dispersion of frankincense extract is characterized by consisting of frankincense extract and a carrier material, wherein the frankincense extract is the mixture of the total triterpene components of frankincense; the carrier material is macromolecular polymer or surfactant; and the mass ratio of the frankincense extract to the carrier material is (50:1)-(1:30). Through the invention, the problem of low bioavailability of the frankincense extract is solved, the bioavailability of the total triterpenes of frankincense can be obviously improved, the industrial production of the preparation thereof can be realized, and conditions are created for the clinical application of frankincense; and the preparation method has wide application range and simple and feasible technology.

Description

technical field [0001] The invention relates to a solid dispersion of frankincense extract and a preparation method thereof, belonging to the field of pharmaceutical intermediates and preparation thereof. Background technique [0002] The traditional Chinese medicine frankincense has a wide range of pharmacological effects. Experiments have proved that frankincense has the effects of promoting blood circulation, relieving pain, reducing swelling and promoting muscle growth. Used alone or in combination with other drugs to treat dysmenorrhea, amenorrhea, rheumatic arthralgia, bruises, etc. At present, the raw powder of frankincense is used directly as medicine in clinical practice, and it is made into pills, powders or ointments for external use. Because frankincense is insoluble in water, it cannot be decocted into effective ingredients directly into decoction, so it is not used as decoction in clinical practice. [0003] Studies have found that boswellia triterpene acid i...

Claims

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Application Information

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IPC IPC(8): A61K36/324A61K9/14A61K47/32A61K47/34A61P19/02A61P29/00
Inventor 李洁许飞路杰崔美兰
Owner SHANDONG QIDU PHARMA
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