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Liquid molecular iodine disinfectant, preparation method and used container

A disinfection preparation and molecular technology, applied in the field of medicine, can solve the problems of affecting iodine sterilization effect, affecting sterilization effect, skin irritation effect, etc., and achieve the effects of prolonging disinfection and sterilization time, good killing effect and good stability

Inactive Publication Date: 2012-09-26
WINERGEN TECH WEIFANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the currently used iodine preparations have great defects: such as iodine (tincture of iodine), etc., have strong dyeing properties, allergies of excipients and low activity
The main reason for the low activity of the current iodine preparations is that the content of free iodine molecules in the entire iodine preparation is too low, and its content continues to decrease over time, while the content of other forms of iodine ions with weak bactericidal effects is low. very high
This not only affects the bactericidal effect of iodine, but also has a strong stimulating effect on human skin, and will produce strong yellow dyeing at the action site, affecting the appearance
And because iodine is volatile, if iodine is placed in the form of molecules for a long time, the content of active ingredients will drop a lot, which will affect the final use of bactericidal effect
In order to ensure the disinfection effect of iodine (tincture of iodine), a higher iodine concentration is generally used, which leads to greater skin irritation when used
These defects greatly limit the scope of application of iodine

Method used

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  • Liquid molecular iodine disinfectant, preparation method and used container
  • Liquid molecular iodine disinfectant, preparation method and used container
  • Liquid molecular iodine disinfectant, preparation method and used container

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolve 1 g of sodium iodide and 0.3 g of potassium periodate in water at room temperature, add 0.1 g of alkaline pH regulator potassium carbonate, 20 g of absolute ethanol, 5 g of propylene glycol, 0.1 g of menthol, and 0.1 g of methylparaben, Make up 73.4g of water, mix and dissolve completely to obtain solution 1. The pH of the solution 1 was 6.5 or more. Dissolve 3.5 g of phosphoric acid, an acidic pH regulator, in 71.3 g of water at room temperature, add 20 g of absolute ethanol, 5 g of propylene glycol, 0.1 g of menthol, and 0.1 g of methylparaben, and mix and dissolve completely to obtain solution 2.

[0041] When in use, mix and dissolve according to the ratio of solution 1, solution 2 and water at 1:1:10 (that is, 1 gram of solution 1 and 1 gram of solution 2 are dissolved in 10 grams of water), and then it can be made into a disinfectant Disinfect and sterilize.

[0042]After testing, the iodine disinfectant of this embodiment has an average killing logarit...

Embodiment 2

[0044] Dissolve 8g of sodium iodide and 2g of sodium iodate in water at room temperature, add 0.2g of sodium bicarbonate, 25g of absolute ethanol, make up 64.8g of water, mix and dissolve completely to obtain solution 1. The pH of the solution 1 was 6.5 or more. Dissolve 20 g of tartaric acid in 55 g of water at room temperature, add 25 g of absolute ethanol, mix and dissolve completely to obtain solution 2.

[0045] When in use, mix and dissolve according to the ratio of solution 1, solution 2 and water at 1:1:100 (that is, 1 gram of solution 1 and 1 gram of solution 2 are dissolved in 100 grams of water), and then it can be made into a disinfectant Disinfect and sterilize.

[0046] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia coli in 5 mi...

Embodiment 3

[0048] Dissolve 20 g of potassium iodide and 5 g of potassium iodate in water at room temperature, add 2 g of sodium carbonate, make up 73 g of water, mix and dissolve completely to obtain solution 1. The pH of the solution 1 was 6.5 or more. Dissolve 20g of phosphoric acid in 80g of water at room temperature, mix and dissolve completely to obtain solution 2.

[0049] When in use, mix and dissolve according to the ratio of solution 1, solution 2 and water at 1:1:100 (that is, 1 gram of solution 1 and 1 gram of solution 2 are dissolved in 100 grams of water), and then it can be made into a disinfectant Disinfect and sterilize.

[0050] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia coli in 5 minutes >5.00.

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Abstract

The invention discloses a liquid molecular iodine disinfectant, which comprises an iodide, an oxidant and an acidity pH regulator, wherein the oxidant can be used for oxidizing the iodide to generate iodine molecules, and the acidity pH regulator is used for regulating a mixture of the iodide and the oxidant to be acid. The disinfectant consists of a composition of a preparation 1 containing the iodide and the oxidant and a preparation 2 containing the acidity pH regulator; the preparation 1 and the preparation 2 are in a liquid state respectively; and the pH value of the preparation I is greater than 6.5. The liquid molecular iodine disinfectant disclosed by the invention not only is high in stability, can be stored for a long time, is light in irritation to skins, rapid in penetration and volatilization, light in coloring and obvious in sterilizing effect and does not need to be de-iodinated but also is safe and convenient in use and carrying. The liquid molecular iodine disinfectant disclosed by the invention has a broad-spectrum sterilizing effect and is light in irritation to skin mucosae and can be used for various skin diseases caused by bacteria, fungi and viruses.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a liquid molecular iodine disinfection preparation for skin disinfection. Background technique [0002] Iodine is a commonly used disinfection product, especially preparations such as iodine (tincture of iodine) are familiar disinfection products, and are widely used in hospitals and daily life. Iodine is one of the broadest-spectrum disinfectants, which can kill 100% of various bacteria, fungi, viruses and other microorganisms without producing drug resistance. So far, no microorganisms resistant to iodine have been found in the world. [0003] However, there are great defects in the currently used iodine preparations: such as iodine (tincture of iodine) etc. have strong dyeing properties and allergies of auxiliary materials and low activity. The main reason for the low activity of the current iodine preparations is that the content of free iodine molecules in the entire iodi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18B65D81/32B65D47/36B65D47/38A61P31/02A61P17/00
Inventor 郑中立孙国玲
Owner WINERGEN TECH WEIFANG
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