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Cefradine-borneol composition

A technology of cephradine and its composition, which is applied in the field of cephradine borneol composition, can solve the problems such as the increase of drug-resistant bacteria, the increase of sensitivity, and the increase of dosage, so as to achieve the effect of improving the phenomenon of drug resistance and having broad application prospects

Inactive Publication Date: 2012-09-19
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a kind of cephradine borneol composition to improve the sensitivity of these drug-resistant bacterial strains to the drug for the deficiencies such as the increase of drug-resistant bacteria, the inconspicuous therapeutic effect of cephradine, and the increase in dosage in the prior art.

Method used

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  • Cefradine-borneol composition
  • Cefradine-borneol composition
  • Cefradine-borneol composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 antibacterial experiment

[0020] Get the cephradine borneol composition and carry out antibacterial experiment.

[0021] Simple borneol group:

[0022] Take a sterilized test tube, add 7.2mL of LB medium to tube 1, then add 0.8mL of borneol liquid, take out 4mL of the mixed solution from tube 1 by the 2-fold dilution method, place it in test tube 2 containing 4mL of LB medium, and mix Mix well, dilute to the 8th tube according to law, take out 4mL, and discard. Add 0.1 mL of bacterial suspension with a turbidity of 1 McFarland unit to each tube, and shake well.

[0023] Simple cephradine group:

[0024] Take a sterilized test tube, add 7.2mL of LB medium to tube 1, then add 0.8mL of cefradine liquid, take out 4mL of the mixed solution from tube 1 by the 2-fold dilution method, place it in test tube 2 containing 4mL of LB medium, and mix Mix well, dilute to the 8th tube according to law, take out 4mL, and discard. Add 0.1 mL of bacterial suspension wi...

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Abstract

The invention discloses a cefradine-borneol composition belonging to the technical field of the preparation of medicines. The cefradine-borneol composition comprises cefradine and borneol according to the mass ratio of 1:0.1 to 1:10, wherein the optimal mass proportion is 1:1. The composition can be prepared into various medicament forms, such as tablets, capsules, granules, slow release preparations and injections, by using a conventional medicine preparation method and auxiliary materials which are universal pharmaceutically. The composition has a very good inhibiting action to various medicine-resistant bacteria, and the minimal inhibitory concentration (MIC) value is lowered at an order of magnitude. Therefore, the phenomenon of medicine resistance of common antibiotics is greatly improved, and the application prospect is extensive.

Description

technical field [0001] The invention relates to the field of antibacterial drugs, in particular to a cephradine borneol composition. Background technique [0002] Cephradine, chemical name: (6R,7R)-7[(R)-2-amino-2-(1,4-cyclohexenyl)acetamido]-3-methyl-8-oxo-5- Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid, formula C 16 h 18 N 2 o 4 S, the structural formula is as formula (Ⅰ) [0003] [0004] ( ) [0005] This product is a first-generation cephalosporin with similar antibacterial activity to cephalexin. The MICs against penicillinase-free and penicillinase-producing Staphylococcus aureus are 0.04 μg / ml and 0.05~0.1 μg / ml, respectively. Except Enterococcus and methicillin-resistant Staphylococcus aureus which are resistant to this product, other Gram-positive cocci and bacilli are highly sensitive to this product. It also has antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Neisseria gonorrhoeae, Haemophilus influenz...

Claims

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Application Information

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IPC IPC(8): A61K31/545A61P31/04A61P31/10A61K31/045
CPCY02A50/30
Inventor 李明亚陈燕忠冼嘉雯
Owner GUANGDONG PHARMA UNIV
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