Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel asymmetric phase-transfer catalyst pentaazabicyclo and preparation method thereof

A phase transfer catalyst, asymmetric technology, applied in chemical instruments and methods, preparation of imino compounds, catalysts for physical/chemical processes, etc., can solve problems such as inability to widely use organic synthesis reactions, insufficient catalyst activity, and large catalyst dosage. , to achieve the effect of a wide range of industrial applications, a wide range of applications, and low production costs

Inactive Publication Date: 2012-09-12
RAFFLES PHAMRMATECH CO LTD
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cinchona alkali is not easy to modify its structure, which greatly limits the wider application of this type of catalyst.
[0012] 2. The amount of cinchona alkali catalyst usually needs to be 10mol%, indicating that the activity of the catalyst itself is not strong enough
In the case that the catalyst cannot be recycled, it means that the catalyst is used in a large amount and the cost is high
[0013] 3. Existing catalysts are still only suitable for certain types of substrates and reactions
Not widely used in organic synthesis reactions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel asymmetric phase-transfer catalyst pentaazabicyclo and preparation method thereof
  • Novel asymmetric phase-transfer catalyst pentaazabicyclo and preparation method thereof
  • Novel asymmetric phase-transfer catalyst pentaazabicyclo and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the appended tables in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0030] The present invention provides a kind of synthetic route of novel asymmetric phase transfer catalyst pentaazabicyclic as follows:

[0031]

[0032] Reaction condition: step (i) adds triphosgene or thiophosgene, triethylamine; Step (ii) adds RX, NaH; Step (iii) adds oxalyl chloride, refluxes; Step (iv) adds ammonia, refluxes; Step ( v) add triethylamine and the product of step iii.

[0033] Specifically, Embodiment 1 of the present invention pro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel asymmetric phase-transfer catalyst pentaazabicyclo and a preparation method thereof. A unique bran-new synthetic route is adopted: different chiral amines, which are used as the initial raw material, react with different halogenated hydrocarbons to synthesize the catalyst pentaazabicyclo with different structural formulae. The catalyst has the advantages of low consumption and high efficiency in the synthetic reaction, can easily change the structure, and thus, is suitable for various different substrates and wide asymmetric reactions.

Description

technical field [0001] The invention belongs to the field of organic compound synthesis, and in particular relates to a phase transfer catalyst and a preparation method thereof. Background technique [0002] Asymmetric phase transfer catalysis is one of the most effective methods in organic synthesis. Generally, phase transfer catalysis has the advantages of simple operation, mild conditions, suitable for scale-up, and easy catalyst recovery. Therefore, phase-transfer catalysis is one of the most important organic synthesis methods today, and it has also been widely used in industrial processes. The most common phase transfer catalysts are quaternary ammonium salts. At present, asymmetric phase transfer catalysts are mainly divided into the following three categories: 1. Derivatives of cinchona base; 2. Maruoka's binaphthol-derived chiral quaternary ammonium salts with C2-symmetry axis; 3. Other categories . [0003] In the 1980s, the main chiral phase transfer catalysts ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/02C07D233/52C07D235/02C07C251/24C07C249/02
Inventor 叶伟平徐俊烨
Owner RAFFLES PHAMRMATECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products