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Preparation method of nifuroxazide premix

A technology of nifurol hydrazide and nifurol hydrazide grinding, which is applied in the field of preparation of nifurol hydrazide premix, can solve the problems of unreported, patent application and the like, achieves balanced dosage and simple and easy preparation method line, improve the effect of use

Inactive Publication Date: 2013-04-17
张奎昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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Examples

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Effect test

Embodiment 1

[0023] Take 5 kg of nifurofen hydrazide and crush it through a 800-mesh sieve to obtain a fine powder, mix it with 2.5 kg of sodium humate 350-mesh fine powder, and directly press it into granules with a dry granulator. The particle size of the granules is 85-100 mesh. Put the prepared nitrofuran hydrazide granules and 92.5 kg of soybean meal powder with a particle size of 85 to 100 mesh into a 300-liter three-dimensional mixing mixer, stir and mix evenly, stop stirring after measuring the coefficient of variation ≤ 5%, and obtain Finished nifurofarzide premix.

Embodiment 2

[0025] Take 5kg of nifurofen hydrazide and crush it through a 800 mesh sieve to obtain a fine powder, mix it with 3kg of sodium humate 350 mesh fine powder, and directly press it into granules with a dry granulator. The particle size of the granules is 85-100 mesh. The prepared nitrofuran hydrazide granules and 92kg of bran with a particle size of 85-100 meshes were put into a 300-liter three-dimensional mixing mixer, stirred and mixed evenly, and the stirring was stopped after the measured variation coefficient was ≤4%, and the finished nitrate was obtained. Fufenozide premix.

Embodiment 3

[0027] Take 5 kg of nifurofen hydrazide and crush it through a 900-mesh sieve to obtain a fine powder, mix it with 3.5 kg of sodium humate 350-mesh fine powder, and directly press it into granules with a dry granulator. The particle size of the granules is 85-100 mesh. Put the prepared nitrofuran hydrazide granules and 91.5 kg of rice bran with a particle size of 85-100 mesh into a 300-liter three-dimensional mixing mixer, stir and mix evenly, and stop stirring after measuring the coefficient of variation ≤ 5%, and the finished product is obtained Nifurofen hydrazide premix.

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Abstract

The invention provides a preparation method of a nifuroxazide premix. The nifuroxazide premix consists of nifuroxazide and sodium humate powder in a weight ratio of 1:0.5-1; the nifuroxazide and the sodium humate powder are directly pressed into particles of 85-100 meshes, then a carrier substance with particle diameter of 85-100 meshes is added and the materials are added into a stirrer to be uniformly stirred to obtain the finished product nifuroxazide premix, wherein the content of the amount of the added nifuroxazide is 5-20 percent by weight in the nifuroxazide premix. The nifuroxazide premix prepared by the invention is fine spherical particles, and the fluidity and the dispersibility of the nifuroxazide premix are improved, so that the mixing uniformity of the nifuroxazide premix and a feed is also improved, and dosage balance of a medicament of the nifuroxazide premix is facilitated during feeding of livestock.

Description

technical field [0001] The invention relates to the technical field of a veterinary drug premix, in particular to a preparation method of a nifurofen hydrazide premix. Background technique [0002] Nifuroxazide, also known as nifurazide, is a nitrofuran antineoplastic drug in human medicine, and is clinically used to treat colitis and diarrhea. Nifurofen hydrazide has a broad antibacterial spectrum, high antibacterial activity, and low inhibitory concentration. It has no cross-resistance with sulfonamides, quinolones and other antibiotics. Its antibacterial activity is hardly affected by other organic substances, and its effect is stable. Because this product can effectively prevent and treat intestinal or urinary system diseases caused by E. Feed by animals, it is the only new high-efficiency feed additive for animals by the European Community law. In recent years, it has also been developed and applied by veterinary drug and feed additive manufacturers in my country. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K35/02A61P31/04A61P33/02A61P31/10A23K1/17A61K31/345A23K20/195
Inventor 张奎昌张婷婷张路
Owner 张奎昌
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