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Method for preparing diclazuril solid dispersion

A technology of solid dispersion and diclazuril, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, active ingredients of heterocyclic compounds, etc., can solve the problems of clinical application, affect the promotion of use, and the poor water solubility of diclazuril and other problems, to achieve the effect of simple preparation process and improved solubility

Inactive Publication Date: 2012-09-12
QINGDAO LVMAN BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the poor water solubility of diclazuril, it has brought great trouble to clinical application and affected its popularization and use.

Method used

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  • Method for preparing diclazuril solid dispersion
  • Method for preparing diclazuril solid dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of diclazuril solid dispersion is characterized in that it is carried out as follows: (every part is calculated by 10g)

[0019] (1) Take by weight 100 parts of Clazuril (over 80 mesh sieves), 1000 parts of polyethylene glycol-4000, and 100 parts of dimethylacetamide;

[0020] (2) Dissolving the diclazuril in dimethylacetamide, stirring until uniform;

[0021] (3) Quickly add the mixture obtained in (2) into the melted polyethylene glycol-4000, stir evenly, rapidly cool to about -10°C, and pulverize to obtain the solid dispersion of diclazuril.

Embodiment 2

[0023] A preparation method of diclazuril solid dispersion is characterized in that it is carried out as follows: (every part is calculated by 10g)

[0024] (1) Take by weight 120 parts of Clazuril (through 80 mesh sieve), 1250 parts of polyethylene glycol-4000, 120 parts of dimethylacetamide;

[0025] (2) Dissolving the diclazuril in dimethylacetamide, stirring until uniform;

[0026] (3) Quickly add the mixture obtained in (2) into the melted polyethylene glycol-4000, stir evenly, rapidly cool to about -10°C, and pulverize to obtain the solid dispersion of diclazuril.

Embodiment 3

[0028] A preparation method of diclazuril solid dispersion is characterized in that it is carried out as follows: (every part is calculated by 10g)

[0029] (1) Take by weight 150 parts of Clazuril (over 80 mesh sieves), 1500 parts of polyethylene glycol-4000, and 150 parts of dimethylacetamide;

[0030] (2) Dissolving the diclazuril in dimethylacetamide, stirring until uniform;

[0031] (3) Quickly add the mixture obtained in (2) into the melted polyethylene glycol-4000, stir evenly, rapidly cool to about -10°C, and pulverize to obtain the solid dispersion of diclazuril.

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Abstract

The invention discloses a method for preparing a diclazuril solid dispersion, relating to the field of animal medicines. The diclazuril solid dispersion disclosed by the invention is uniformly and sequentially prepared by using the following components in parts by weight: 10-15 parts of diclazuril (sieved by an 80-mesh sieve), 100-150 parts of polyethylene glycol-4000 and 10-15 parts of dimethylacetamide. The preparation method comprises the following steps of: (1) weighing 10-15 parts of the diclazuril (sieved by the 80-mesh sieve), 100-150 parts of the polyethylene glycol-4000 and 10-15 parts of the dimethylacetamide in parts by weight; (2) dissolving the diclazuril in the dimethylacetamide, and uniformly stirring; and (3) rapidly adding the mixture obtained in the step (2) in the molten polyethylene glycol-4000, uniformly stirring, rapidly cooling to about minus 10 DEG C, and smashing to obtain the diclazuril solid dispersion. The method disclosed by the invention is simple in preparation process and has the advantages that the solubility of the diclazuril is significantly improved and the dissolution rate is about 2 times of that of a common diclazuril preparation (soluble powder or oral liquid).

Description

technical field [0001] The invention relates to the field of animal medicine, in particular to a preparation method of diclazuril solid dispersion. Background technique [0002] Diclazuril is off-white or light yellow powder; almost odorless. This product is slightly soluble in dimethylformamide, slightly soluble in tetrahydrofuran, almost insoluble in water and ethanol. It is a new type, high efficiency and low toxicity anticoccidiostat, which is widely used in the prevention and treatment of chicken coccidiosis. [0003] Due to diclazuril's poor water solubility, it has brought great troubles to clinical application and affected its popularization and use. Therefore, developing a new technology to overcome the above-mentioned shortcomings of diclazuril is one of the new issues to be solved urgently by scientific researchers and technicians in this field. Contents of the invention [0004] The purpose of the present invention is to overcome the above disadvantages and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/53A61K47/34A61P33/02
Inventor 周庆福刘文利
Owner QINGDAO LVMAN BIOLOGICAL ENG
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