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Microfluidic separation of plasma for colormetric assay

A plasma separation membrane, plasma technology, applied in the field of plasma microfluidic separation for colorimetric determination

Active Publication Date: 2012-08-29
HONEYWELL INT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no commercial product capable of extracting plasma from a single drop of blood (finger stick, 20-30 μL of blood)

Method used

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  • Microfluidic separation of plasma for colormetric assay
  • Microfluidic separation of plasma for colormetric assay
  • Microfluidic separation of plasma for colormetric assay

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0059] 1. A device comprising:

[0060] plasma separation membrane;

[0061] a capillary channel positioned adjacent to the plasma separation membrane for receiving plasma from blood on the plasma separation membrane;

[0062] at least one cuvette connected to the capillary channel;

[0063] gas permeable membrane; and

[0064] A dispensing channel connected to the capillary channel for supplying plasma to a cuvette, wherein the cuvette is configured to hold an amount of plasma containing reagents suitable for colorimetric determination by a detector holding the device.

[0065] 2. The device according to embodiment 1, characterized in that the plasma separation membrane is located above the capillary channel.

[0066] 3. The device according to embodiment 2, further comprising a port connecting the air source and the capillary channel to generate different pressures on both sides of the plasma separation membrane.

[0067] 4. The device of embodiment 3, wherein the air so...

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PUM

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Abstract

The invention refers to microfluidic separation of plasma for colormetric assay. A device includes a plasma separation membrane (110), a capillary channel (115) positioned adjacent the plasma separation membrane to receive plasma from blood placed on the plasma separation membrane, at least one cuvette (125, 245, 250, 255, 260, 332, 334, 336, 338, 342, 344, 346, 348, 420, 425, 430, 435.540, 545, 550, 555, 650, 652, 656) coupled to the capillary channel, a gas permeable membrane (150, 270, 350, 355, 622), and a distribution channel (120, 230, 235, 240, 325, 330, 525, 530, 545, 630) coupled to the capillary channel to provide plasma to the cuvette, wherein the cuvette is configured to hold an amount of plasma with reagent suitable for colorimetric assay by a tester to hold the device. Variations include the use of a quantiation channel (612) to provide a selected amount of plasma and a mixing channel (616) to mix plasma with a diluent.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Application 61 / 446,924, entitled Isolation, Quantification, and Continuous Preparation of Plasma for Use in Colorimetric Assays in Microfluidic Format, filed February 25, 2011, which is incorporated herein by reference Apply. Background technique [0003] Existing equipment provides the desired amount of blood plasma from human whole blood by using separation equipment and procedures to separate the plasma and then prepares samples for colorimetric determination of blood components, or this supply of plasma and preparation of samples is due to the large blood The inefficient use of samples results in the need for larger blood samples. [0004] With most existing systems, clinical chemistry analyzers do not extract plasma or serum from blood as part of the analysis step. This is done independently; either at the time of collection from the patient by collecting the blood in serum or plasm...

Claims

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Application Information

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IPC IPC(8): G01N21/78G01N1/34
CPCB01L3/502753B01L2200/0647B01L2300/0681B01L2300/0867B01L2400/0481G01N33/491Y10T436/255G01N1/28G01N1/34
Inventor L·塞弗里德R·巴德尔
Owner HONEYWELL INT INC
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