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Preparation method for geum aleppicum polyphenol

A drying and extracting technology, applied in the field of roadside green polyphenols preparation, can solve the problems of large product loss, cumbersome operation, long cycle, etc., and achieve the effect of less solvent usage, good separation effect and complete extraction

Inactive Publication Date: 2012-08-29
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional polyphenol preparation process includes steps such as organic solvent extraction, membrane separation and column chromatography, and has the following disadvantages: 1. It pollutes the environment, and a large amount of toxic reagents are used in the preparation process, which pollutes the environment and is unsafe; 2. Not suitable for large-scale production, the existing process is cumbersome, complicated, long cycle, and large product loss

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dry the whole grass of roadside green grass, crush it, take 1kg, put it into the extraction tank, and use supercritical CO 2 Extraction, the extraction conditions are: extraction pressure 15MPa, extraction temperature 45°C, extraction time 1.5h, analysis pressure 5MPa, temperature 38°C, CO 2 The flow rate is 18L / h, the entrainer is 65% ethanol solution, and the amount added is 20% of the amount of medicinal materials. Collect the polyphenol extract, add water to disperse, and adsorb through the H-1020 macroporous resin column. First, wash away impurities with 5BV distilled water , and then eluted with 5BV70% ethanol solution, the flow rate was controlled to be 0.5BV / h, the eluate was collected, concentrated in vacuo, and dried at low temperature to obtain 16.2g of roadside green polyphenols with a content of 96.0%.

Embodiment 2

[0021] Dry the whole grass of roadside green grass, crush it, take 1kg, put it into the extraction tank, and use supercritical CO 2 Extraction, the extraction conditions are: extraction pressure 28MPa, extraction temperature 30°C, extraction time 3h, analysis pressure 8MPa, temperature 35°C, CO 2 The flow rate is 20L / h, the entraining agent can choose acetone, methanol, ethanol solution, preferably ethanol solution, the volume percentage is 65%, the amount added is 10% of the medicinal material, collect the polyphenol extract, add water to disperse, and pass through H-103 Porous resin column adsorption, first wash away impurities with 4BV distilled water, then elute with 4BV65% ethanol solution, control the flow rate at 0.5BV / h, collect the eluate, concentrate in vacuum, and dry at low temperature to obtain 13.7g of roadside green polyphenols , the content is 95.7%.

Embodiment 3

[0023] Dry the whole grass of roadside green grass, crush it, take 1kg, put it into the extraction tank, and use supercritical CO 2 Extraction, the extraction conditions are: extraction pressure 18MPa, extraction temperature 35°C, extraction time 1h, analytical pressure 6MPa, temperature 35°C, CO 2 The flow rate is 15L / h, the entrainer can choose acetone, methanol, ethanol solution, preferably ethanol solution, the volume percentage is 65%, the amount added is 15% of the medicinal material, collect the polyphenol extract, add water to disperse, and pass through X-5 large Porous resin column adsorption, first wash away impurities with 6BV distilled water, then elute with 5BV60% ethanol solution, control the flow rate at 0.6BV / h, collect the eluate, concentrate in vacuum, and dry at low temperature to obtain 15.9g of roadside green polyphenols , the content is 94.2%.

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Abstract

The invention relates to a preparation method for geum aleppicum polyphenol, which specifically comprises the following steps of preparing materials, carrying out supercritical CO2 extraction, macroporous resin adsorption, condensing, drying and the like. In the technical steps of the preparation method disclosed by the invention, water and ethanol are selected as solvents, and therefore the environment pollution is small. Because the use amount of organic solvent is reduced, the environment can be effectively protected. The preparation method for the geum aleppicum polyphenol has the advantages of effective environment protection, good safety, high production efficiency, short period and good product quality and is suitable for large-scale industrial production. Because the supercritical extraction is adopted, the polyphenol is unlikely to oxidize and has stable property.

Description

Technical field: [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a preparation method of roadside green polyphenols. Background technique: [0002] Studies have shown that plant polyphenols are an excellent food antioxidant that can delay human aging, eliminate active free radicals in the body and resist oxidation. It is known as the "seventh type of nutrient". The application of polyphenol compounds has become a major research hotspot. [0003] Lubianqing is the dry whole plant of the perennial herbaceous plant Lubianqing in the family Rosaceae. It is bitter in nature and pungent and cold. Symptoms such as surface deficiency and cold, cough and hematemesis, deficiency and cold abdominal pain, irregular menstruation, sores, swelling and fractures are currently mainly used as Chinese herbal medicines in clinical practice, and there are few research reports on the extraction and separation of active components of Lubianqin...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P9/00A61P35/00A61P39/00A61P39/06
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司
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