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Preparation method of rat model with hypertension complicated by hyperlipidemia

A rat model, hyperlipidemia technology, applied in the field of medicine, can solve the problems of single therapeutic effect of chemical drugs, no improvement of complications, etc.

Inactive Publication Date: 2012-08-22
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

[0004] At present, the therapeutic effect of chemical drugs is relatively single, and most of them stay in the treatment of hypertension or hyperlipidemia alone, and most of them have no effect on improving complications.

Method used

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  • Preparation method of rat model with hypertension complicated by hyperlipidemia
  • Preparation method of rat model with hypertension complicated by hyperlipidemia
  • Preparation method of rat model with hypertension complicated by hyperlipidemia

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Experimental program
Comparison scheme
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Embodiment 1

[0009] 1 Experimental materials and instruments

[0010] 1.1 Animals WKY rats, 10 males, 180-220g, purchased from Shanghai Slack Experimental Animal Co., Ltd., license number: SCXK (Shanghai) 2007-0005; SHR rats, 10 males, 180-220g , purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2006-0009.

[0011] 1.2 Modeling materials: High-fat feed formula is 77.5% of ordinary feed, 10% of lard, 2% of cholesterol, 0.5% of No. 3 bile salt, and 10% of egg yolk powder

[0012] 1.3 Instruments Selectre-E automatic biochemical analyzer, Rittal, Holland; ALC non-invasive tail artery manometry, Shanghai Alcott Biotechnology Co., Ltd.

[0013] 1.4 Reagent cholesterol (TC), triglyceride (TG) (Shanghai Fosun Long March Medical Science Co., Ltd.); high-density lipoprotein (HDL) test kit (Nanjing Wittman Biotechnology Co., Ltd.);

[0014] 2 Experimental methods

[0015] 2.1 Modeling 10 SHR male rats were used as the model control group...

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Abstract

The invention aims to establish a rat model concerning pharmacodynamic screening, pharmological study and efficacy evaluation of a traditional Chinese medicine for treating concomitant hyperlipidemia and hypertension. On the basis of a hypertension rat model, model set rats are fed with high fat diet each day continuously for 2-6 weeks so as to create a hypertension complicated by hyperlipidemia model. The characteristic indicators of the model are mainly that the total cholesterol and triglyceride as well as low density lipoprotein cholesterin can be increased, and high-density lipoprotein cholesterol can be decreased while the blood pressure is increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing a rat model of hypertension complicated with hyperlipidemia. The model can be used for drug efficacy screening, pharmacological research and drug efficacy evaluation of traditional Chinese medicines for treating hypertension with hyperlipidemia. mouse model. Background technique [0002] Hyperglycemia and hyperlipidemia, diabetes, hyperuricemia and gout are collectively referred to as "four highs". With the improvement of people's living standards and changes in food culture, the incidence of the four highs is gradually increasing and becoming younger. Hypertension accompanied by elevated blood lipids is a common clinical syndrome and is also the pathogenesis basis of ischemic cardiovascular and cerebrovascular diseases. Therefore, it has attracted more and more attention. This type of disease has a long course and many complications. The imp...

Claims

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Application Information

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IPC IPC(8): A01K67/02A23K1/18A61B19/00
Inventor 吕圭源陈素红苏洁牟秀华
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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