Production technology of inositol nicotinate

A technology of inositol nicotinate and production process, applied in the direction of organic chemistry and the like, can solve problems such as serious environmental pollution, waste, and pollution of the environment, and achieve the effect of protecting the ecological environment and reducing production costs

Active Publication Date: 2012-08-08
TIANJIN ZHONGRUI PHARMA
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  • Abstract
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Problems solved by technology

This not only causes a lot of waste of raw materials and energy man-hours, but also seriously pollutes the environment.
[0004] Due to the large consumption of raw materials, seri...

Method used

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Embodiment Construction

[0019] The present invention is further described below.

[0020] Inositol nicotinate production process of the present invention, carry out according to the following steps:

[0021] 1. Chlorination reaction: Add 100kg of pyridine with a water content of no more than 0.5% into a dry 1000L enamel reaction tank, then add 107kg of phosphorus oxychloride, stir well, and gradually add 150kg of nicotinic acid under cooling conditions. Heat up to 65-75°C, keep warm for 0.8-1.2 hours;

[0022] 2. Esterification reaction: Add inositol slowly under cooling conditions, heat up to 80-90°C after adding inositol, and react for about 1 hour;

[0023] 3. Filtration and washing water: stir the reactant with drinking water, and then carry out filtration after cooling. The resulting filtrate is washed with hot purified water until the liquid has no bitter taste of pyridine, and the filter cake is dried to obtain inositol nicotinate Crude;

[0024] 4. Decolorization and refining: dissolve the...

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Abstract

The invention discloses a production technology of inositol nicotinate, and changes the recovery method of pyridine to alkali ion layering method. By using the principle of like polarity ion effect, the invention employs sodium hydroxide to dissociate salified pyridine, and subjects a mixture of pyridine and water to effective layering, thus achieving the purpose of pyridine recovery. Changing dichlorobenzene extraction method to alkali ion layering method reduces the unit consumption of pyridine by 91.5%, and nonuse of dichlorobenzene any more reduces dichlorobenzene consumption to zero, thus effectively reducing production cost, realizing energy saving, emission lowering and consumption reduction, as well as ecological environment protection.

Description

technical field [0001] The invention relates to the field of raw materials for medicine and food production, and more specifically relates to a new process for producing inositol nicotinate. Background technique [0002] Inositol nicotinate is a mild peripheral vasodilator, which can lower cholesterol and expand peripheral blood vessels. It is an auxiliary drug and nutritional food additive for hypercholesterolemia and atherosclerosis. Inositol nicotinate is gradually hydrolyzed into nicotinic acid and inositol in the body, so it has the pharmacological effects of both nicotinic acid and inositol. Inositol nicotinate has a lipid-lowering effect, and its vasodilator effect is milder and longer-lasting than that of niacin. There are no side effects such as flushing and stomach discomfort after taking niacin. Inositol nicotinate can selectively dilate blood vessels in diseased areas and sensitive areas stimulated by cold, while the dilation effect on normal blood vessels is we...

Claims

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Application Information

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IPC IPC(8): C07D213/803
Inventor 高占友刘长锁马秀玲冯培新
Owner TIANJIN ZHONGRUI PHARMA
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