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Solid preparation of compound ammonia phenol renin medicine composition liposome

A technology of compound paracetamol and solid preparation, applied in the field of medicine, can solve problems such as increasing the retention time of medicines

Inactive Publication Date: 2012-08-01
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through a large number of experiments, it has been found that the liposome solid preparation made of specific excipients and compound aminophenol renin pharmaceutical composition effectively overcomes the problem of poor stability of the main drug, improves the dissolution rate of the drug, and increases the concentration of the drug. retention time in vivo

Method used

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  • Solid preparation of compound ammonia phenol renin medicine composition liposome
  • Solid preparation of compound ammonia phenol renin medicine composition liposome
  • Solid preparation of compound ammonia phenol renin medicine composition liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The preparation of embodiment 1 compound aminophenol renin pharmaceutical composition liposome sheet

[0066] Prescription (1000 tablets)

[0067]

[0068] Adopt the following production process to prepare the liposome tablet of compound aminophenol renin pharmaceutical composition:

[0069] (1) 250g paracetamol, 30g anhydrous caffeine, 5g phenylephrine hydrochloride, 2g chlorpheniramine maleate, 3g vitamin B 1 , 200g egg yolk phosphatidylserine, 50g phosphatidylethanolamine, and 10g octadecylamine are dissolved in 5000ml ethanol, mix uniformly, and remove ethanol under reduced pressure on a rotary thin film evaporator to obtain a lipid film;

[0070](2) Add 5000ml of phosphate buffer solution with a pH value of 7.2, shake and stir for 20 minutes at a speed of 500r / min to completely hydrate the phospholipid membrane, and homogenize and emulsify at a high speed for 15 minutes with a tissue masher at a speed of 8000r / min. min, filter with a 0.45 μm microporous membra...

Embodiment 2

[0075] The preparation of embodiment 2 compound aminophenol renin pharmaceutical composition liposome sheet

[0076] Prescription (1000 tablets)

[0077]

[0078] Adopt the following production process to prepare the liposome tablet of compound aminophenol renin pharmaceutical composition:

[0079] (1) 250g paracetamol, 30g anhydrous caffeine, 5g phenylephrine hydrochloride, 2g chlorpheniramine maleate, 3g vitamin B 1 100g egg yolk phosphatidylserine, 100g phosphatidylethanolamine, and 20g octadecylamine are dissolved in 5000ml ethanol, mix uniformly, and remove ethanol under reduced pressure on a rotary thin film evaporator to obtain a lipid film;

[0080] (2) Add 5000ml of phosphate buffer solution with a pH value of 7.2, shake and stir for 20 minutes at a speed of 1000r / min to completely hydrate the phospholipid membrane, and homogenize and emulsify with a tissue masher for 10 minutes at a speed of 8000r / min min, filter with a 0.45 μm microporous membrane to obtain a l...

Embodiment 3

[0085] Preparation of Example 3 Children's compound aminophenol renin pharmaceutical composition liposome tablet

[0086] Prescription (1000 tablets)

[0087]

[0088] Adopt the following production process to prepare the liposome tablet of compound aminophenol renin pharmaceutical composition:

[0089] (1) Add 125g of paracetamol, 2.5g of phenylephrine hydrochloride, 1g of chlorpheniramine maleate, 1g of vitamin B 1 , 75g egg yolk phosphatidylserine, 75g phosphatidylethanolamine, 50g octadecylamine are dissolved in 5000ml ethanol, mix uniformly, remove ethanol under reduced pressure on a rotary thin film evaporator, obtain lipid film;

[0090] (2) Add 5000ml of phosphate buffer solution with a pH value of 7.2, shake and stir for 20 minutes at a speed of 1000r / min to completely hydrate the phospholipid membrane, and homogenize and emulsify with a tissue masher for 10 minutes at a speed of 8000r / min min, filter with a 0.45 μm microporous membrane to obtain a liposome suspe...

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Abstract

The invention discloses a solid preparation of a compound ammonia phenol renin medicine composition liposome and a preparation method thereof. The method comprises that the compound ammonia phenol renin medicine composition liposome is prepared by acetaminophen, anhydrous caffein, phenylephrine hydrochloride, chlorpheniramine maleate, vitamin B1, egg yolk lecithin acyl serine, phosphatidyl ethanolamine and octadecylamine which are selected according to specified weight ratio, and then the solid preparation is prepared by the compound ammonia phenol renin medicine composition liposome through an ordinary preparation method. The solid preparation of the liposome is high in encapsulation and even in particle size, improves quality of a preparation product, reduces toxic and side effects, andis suitable for industrialized production. In addition, the preparation method is simple, and the medicine is reserved in blood circulation for a long time.

Description

technical field [0001] The invention relates to a liposome solid preparation of a compound aminophenol renin pharmaceutical composition and a preparation method thereof. The active ingredients include acetaminophen, anhydrous caffeine, phenylephrine hydrochloride, chlorpheniramine maleate and vitamin B 1 , belonging to the field of medical technology. Background technique [0002] The active ingredients of compound aminophenol renin pharmaceutical composition liposome solid preparation are acetaminophen, anhydrous caffeine, phenylephrine hydrochloride, chlorpheniramine maleate and vitamin B 1 The combination of paracetamol can inhibit the synthesis of prostaglandins and produce antipyretic and analgesic effects; caffeine is a central stimulant, and it can strengthen antipyretic and analgesic effects when used in combination with antipyretic and analgesic drugs; phenylephrine hydrochloride can Shrink the capillaries of the upper respiratory tract, eliminate the congestion of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/51A61K31/4402A61K31/167A61K31/137A61K47/24A61K47/18A61K9/127A61P29/00A61P31/16A61P11/02A61P11/04
Inventor 廖爱国曹仕霞
Owner HAINAN MEIDA PHARMA
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