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Preparation method and standard quality testing method of Yinjusanjie granular preparation

A detection method and granule technology, which is applied in the field of medicine, can solve the problems that the curative effect of medicines cannot be guaranteed, and the quality of products cannot be effectively guaranteed, so as to improve clinical symptoms and improve the effect of antibody turning negative

Inactive Publication Date: 2012-07-25
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is no preparation method and quality standard detection method for "Yinju Sanjie Granules" in the prior art, which cannot effectively guarantee the product quality in production and use, and the curative effect of the drug cannot be guaranteed

Method used

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  • Preparation method and standard quality testing method of Yinjusanjie granular preparation
  • Preparation method and standard quality testing method of Yinjusanjie granular preparation
  • Preparation method and standard quality testing method of Yinjusanjie granular preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Weigh 600g of honeysuckle, 150g of chrysanthemum, 150g of bellflower, 75g of Prunella vulgaris, 450g of Radix Ophiopogon japonicus, and 75g of Scrophulariaceae.

[0140] The above six flavors are extracted twice with water. Add 12 times the amount of water for the first extraction for 1.5 hours, add 10 times the amount of water for the second extraction for 1 hour, combine the liquid medicine, filter, and concentrate the filtrate to a relative density of 1.10-1.15 (60°C), add ethanol to make the alcohol The amount reaches 70%, stir well, stand still for 24 hours, filter, recover ethanol from the filtrate, concentrate to a clear paste with a relative density of 1.15-1.20 (60°C), add an appropriate amount of dextrin, and make granules, a total of 1000g.

[0141] Usage and dosage: oral administration; daily dosage is 20g-40g granules; once a day in the morning and evening; one course of treatment is one month; 3-6 courses of treatment are taken continuously.

Embodiment 2

[0143] Weigh 450g of honeysuckle, 150g of chrysanthemum, 450g of Campanulaceae, 300g of Prunella vulgaris, 150g of Radix Ophiopogon japonicus, and 300g of Scrophulariaceae.

[0144] The above six flavors are extracted twice with water. Add 12 times the amount of water for the first extraction for 1.5 hours, add 10 times the amount of water for the second extraction for 1 hour, combine the liquid medicine, filter, and concentrate the filtrate to a relative density of 1.10-1.15 (60°C), add ethanol to make the alcohol The amount reaches 70%, stir well, stand still for 24 hours, filter, recover ethanol from the filtrate, concentrate to a clear paste with a relative density of 1.15-1.20 (60°C), add an appropriate amount of dextrin, and make granules, a total of 1000g.

Embodiment 3

[0146] Weigh 600g of honeysuckle, 150g of chrysanthemum, 150g of bellflower, 75g of Prunella vulgaris, 450g of Radix Ophiopogon japonicus, and 75g of Scrophulariaceae.

[0147] The above six flavors are extracted twice with water. For the first time, add 10 times the amount of water to extract for 2 hours, and for the second time, add 8 times the amount of water to extract for 1 hour, combine the liquid medicine, filter, concentrate the filtrate to a relative density of 1.10-1.15 (60°C), add ethanol to make the alcohol The amount reaches 70%, stir well, stand still for 24 hours, filter, recover ethanol from the filtrate, concentrate to a clear paste with a relative density of 1.15-1.20 (60°C), add an appropriate amount of dextrin, and make granules, a total of 1000g.

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Abstract

The invention discloses a preparation method of ;Yinjusanjie granular preparation' for treatment of Hashimoto diseases, which comprises the following steps of: weighing honeysuckle, chrysanthemum, campanulaceae, prunella, ophiopogon and scrophulariaceae according to the weight ratio, extracting twice with water, mixing medical solution, filtering, concentrating filtrate until the relative density is 1.10 to 1.15 (at 60 DEG C), adding ethanol for precipitation, concentrating and adding dextrin to prepare grains. The process is simple and reasonable, a large number of active ingredients of the medicine can be maintained, and the production cost is low. In the standard quality testing method, prunella or honeysuckle and chrysanthemum or scrophulariaceae in the Yinjusanjie granular preparation are identified via thin-layer chromatography. The honeysuckle content is determined via high-performance liquid chromatography, and the quality and efficacy of the product-Yinjusanjie granular preparation can be effectively ensured in production and use.

Description

technical field [0001] The invention relates to a medicine preparation method and a quality standard detection method, in particular to a preparation method of Yinju Sanjie Granules and a quality standard detection method, belonging to the field of medicine. Background technique [0002] Hashimoto's disease (HT) is also known as Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, thyroiditis. It was first reported by Hashimoto in 1912. It has been reported that the annual incidence rate is 0.15%, and the incidence rate of this disease has gradually increased in recent years, accounting for about 7.3% to 20.5% of thyroid diseases. Autopsies report that 2% of women have tissue features of the disease. Its clinical manifestation is goiter, and some patients are accompanied by abnormal thyroid function, especially in primary hypothyroidism. [0003] Western medicine treats HT, thyroid hormone replacement therapy is lifelong, once interrupted, hypothyroidism...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/16G01N30/90G01N30/02A61P5/14
Inventor 张为胜李诗标张梅雪冯立娟张晶
Owner JINAN KANGZHONG PHARMA TECH DEV
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