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Amino acid and glucose injection packaged by dual-chambered bag, and preparation method of the injection

A glucose injection and glucose solution technology, which is applied in packaging, food packaging, pharmaceutical packaging, etc., can solve the problems of increasing related substances, deepening the color, and decreasing the content of active ingredients

Active Publication Date: 2012-07-25
SICHUAN KELUN PHARMA RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are obvious defects in the infusion varieties containing both amino acids and glucose in the formula: the mixing of amino acids and glucose in the solution state is prone to interaction (such as Maillard reaction), resulting in darker color of the sample during production and storage, increase of related substances or The content of active ingredients decreases, which greatly affects the safety and effectiveness of product use

Method used

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  • Amino acid and glucose injection packaged by dual-chambered bag, and preparation method of the injection
  • Amino acid and glucose injection packaged by dual-chambered bag, and preparation method of the injection
  • Amino acid and glucose injection packaged by dual-chambered bag, and preparation method of the injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] The raw material composition of amino acid solution is as follows

[0160] Leucine 4.17kg

[0161] Isoleucine 1.87kg

[0162] Lysine acetate 4.13kg

[0163] Methionine 1.17kg

[0164] Histidine 2kg

[0165] Tyrosine 0.116kg

[0166] Alanine 2.07kg

[0167] Glycine 3.57kg

[0168] Aspartic acid 1.27kg

[0169] Glutamic acid 2.17kg

[0170] Proline 1.10kg

[0171] Phenylalanine 3.11kg

[0172] Threonine 2.17kg

[0173] N-acetyl L-tryptophan 0.52kg

[0174] Valine 1.50kg

[0175] Serine 0.73kg

[0176] Arginine 2.63kg

[0177] Cysteine ​​Hydrochloride 0.48kg

[0178] Sodium metabisulfite 1kg

[0179] Water for injection 500kg

[0180] The raw material composition of glucose solution is as follows:

[0181] Glucose 37.5kg

[0182] Water for injection 250l

[0183] The structure of the double chamber bag is as follows:

[0184] A double-chamber aseptic bag, drug dosing plug 1, drug infusion plug 2, protection table 3, independent chamber thermal transfer...

Embodiment 2

[0191] The raw material composition of amino acid is as follows:

[0192] Arginine Hydrochloride 20kg

[0193] Water for injection 500kg

[0194] The raw material composition of glucose solution is as follows:

[0195] Glucose 37.5kg

[0196] Water for injection 250l

[0197] The structure and preparation method of the double-cavity bag are the same as in Example 1.

[0198] The preparation method of the amino acid glucose injection packaged in a double-cavity bag is as follows: take glucose and water for injection to prepare a solution with a concentration of 10%-15%, absorb the solution with 0.1%-0.15% activated carbon, and then decarbonize it with a titanium rod. 0.2μm~0.4μm microporous membrane filtration; take amino acid and water for injection to make a solution, absorb the solution with 0.1%~0.15% activated carbon, then decarbonize with titanium rod, filter through 0.2μm~0.4μm microporous membrane, and finally carry out Nitrogen filling for 15-20 minutes; fill the tw...

Embodiment 3

[0200] The raw material composition of amino acid is:

[0201] Leucine 2.5kg

[0202] Isoleucine 2.7kg

[0203] Lysine acetate 2.5kg

[0204] Methionine 1.3kg

[0205] Histidine 1.3kg

[0206] Tyrosine 0.13kg

[0207] Alanine 1.3kg

[0208] Glycine 5.5kg

[0209] Aspartic acid 1kg

[0210] Glutamic acid 2.7kg

[0211] Proline 0.8kg

[0212] Phenylalanine 4kg

[0213] Threonine 1.3kg

[0214] N-acetyl L-tryptophan 0.7kg

[0215] Valine 1kg

[0216] Serine 1kg

[0217] Arginine 1.5kg

[0218] Cysteine ​​Hydrochloride 0.6kg

[0219] Sodium metabisulfite 0.8kg

[0220] Water for injection 300kg

[0221] The raw material composition of glucose is:

[0222] Glucose 55kg

[0223] Water for injection 150l

[0224] The structure and preparation method of the double-cavity bag are the same as in Example 1.

[0225] The preparation method of the amino acid glucose injection packaged in a double-cavity bag is as follows: take glucose and water for injection to make a ...

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Abstract

The invention discloses a preparation method of amino acid and glucose injection packaged by a dual-chambered bag. The method comprises the steps of using glucose and injection water to prepare a solution; using amino acid and injection water to prepare a solution and charging nitrogen into the solution; feeding the glucose solution and the amino acid solution to two chambers of the dual-chambered bag simultaneously; vacuumizing and then filling nitrogen; loading the filled dual-chambered bag into an outer bag with high barrier; vacuumizing, filling nitrogen for several minutes, and packaging; and putting the packaged dual-chambered bag to a sterilizing device to sterilize at 115-125 DEG C. The amino acid and glucose injection provided by the invention is packaged by the dual-chambered bag. Because the amino acid solution and the glucose solution are fed in two chambers separated by cold solder joint, Maillard reaction or other side effects between amino acid and glucose due to long-term contact during the sterilization and storage are prevented, and then the usage safety and efficiency of the product can be ensured.

Description

technical field [0001] The invention relates to an amino acid glucose injection, in particular to an amino acid glucose injection packed in a double-cavity bag and a preparation method thereof. Background technique [0002] Amino acid is a monomer for protein synthesis in the human body, a nitrogen source for the synthesis of other tissues, and a basic substance for sustaining life. Glucose is the heat source that best meets the physiological needs of the human body. It has the effect of maintaining heat for critically ill patients. Glucose can significantly improve amino acid metabolism after being infused with amino acids, provide energy for protein synthesis, and inhibit the waste of amino acid glycogenesis and promote amino acid metabolism. Therefore, the combined prescription of amino acid and glucose injection is more convenient and reasonable than single amino acid injection. [0003] However, there are obvious defects in the infusion varieties containing both amino ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K31/4172A61K31/405A61K31/401A61K31/198A61K31/195A61P3/02A61J1/10B31B1/00
Inventor 冉良骥朱勇佘佑廷田洪伍龙雯陈莉梁隆王利春沈鑫
Owner SICHUAN KELUN PHARMA RES INST CO LTD
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