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Porous and magnetic anisotropy microspheres and preparation method thereof

An anisotropic and microsphere technology, applied in the field of porous and magnetic polymer materials, can solve problems such as limited applications, inability to meet commercial production, and inability to produce in large quantities

Inactive Publication Date: 2012-07-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can well control the particle size and particle size distribution of the inner and outer emulsion droplets, and can prepare triple emulsions, even five emulsions, and the technology is relatively mature, but the disadvantage is that it cannot be mass-produced, which makes it unable to meet commercial production and limits its application

Method used

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  • Porous and magnetic anisotropy microspheres and preparation method thereof
  • Porous and magnetic anisotropy microspheres and preparation method thereof
  • Porous and magnetic anisotropy microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 0.5 g of FeCl to a three-neck flask equipped with a stirrer 3 ·6H 2 O and 0.2 g FeCl 2 4H 2 O, stir to dissolve, warm up and add 2 ml NH 3 ·H 2 O, the reaction was stirred at 50 °C for 1 h. After the reaction, wash several times with ethanol and ultrapure water and prepare an aqueous dispersion of iron oxide with a concentration of 5 mg / ml; add a mixed solution of ultrapure water and ethanol with a volume ratio of 3:1 in a 100 ml beaker, Add 1 g of CTAB and 2 ml of TEA, stir evenly, then add 2 ml of TEOS at 60°C for reflux reaction for 2 h and wash to prepare an aqueous dispersion with a concentration of 1 wt%. The aqueous dispersion liquid of magnetic iron oxide in ml is the internal aqueous phase, which is added to 1 ml of the polymerizable monomer methyl methacrylate oil phase containing the initiator AIBN and 0.1 wt% hydrophobic silica, and the oil-in-water colostrum is obtained by ultrasonication ; Add 1 ml of this colostrum to 1 ml of ultrapure water con...

Embodiment 2

[0029] The preparation method of the magnetic iron oxide aqueous phase dispersion and the mesoporous silica dispersion is as in Embodiment 1. Take 1 ml of the magnetic iron oxide aqueous phase dispersion with a concentration of 5 mg / ml as the inner water phase, and add it to 5 ml of the initiator-containing In the polymerizable monomer styrene oil phase of BPO and 1 wt% hydrophobic silica, the oil-in-water colostrum was obtained by ultrasonication; then 1 ml of the colostrum was added to 5 ml of mesoporous silica containing 1 wt% ( or clay particles) in ultrapure water to prepare double Pickering emulsions; the prepared double Pickering emulsions were polymerized at 70°C for 18 h under the action of a magnetic field, washed and dried to obtain porous magnetic anisotropy Microspheres.

Embodiment 3

[0031] The preparation method of magnetic iron oxide aqueous phase dispersion liquid and mesoporous silica dispersion liquid is as embodiment one, take 1 ml of magnetic iron oxide aqueous phase dispersion liquid with a concentration of 5 mg / ml as the inner water phase, add it to 10 ml initiator-containing In the polymerizable monomer styrene oil phase of BPO and 2 wt% hydrophobic silica, the oil-in-water colostrum was obtained by ultrasonication; then 1 ml of the colostrum was added to 10 ml of mesoporous silica containing 2 wt% ( or clay particles) in ultrapure water to prepare double Pickering emulsions; the prepared double Pickering emulsions were polymerized at 80°C for 24 h under the action of a magnetic field, washed and dried to obtain porous magnetic anisotropy Microspheres.

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Abstract

The invention belongs to the field of porous and magnetic high polymer materials and particularly relates to porous and magnetic anisotropy microspheres and a preparation method thereof. According to the preparation method of the porous and magnetic anisotropy microspheres, double water-in-oil-in-water (W / O / W) Pickering emulsion serves as a template, aqueous phase dispersion of magnetic iron oxide serves as an inner aqueous phase, oil-solubility polymerizable monomers and an initiator serve as oil phases, and pure water serves as an outer water phase; two solid particles with different hydrophilicity and hydrophobicity serve as emulsifier of inner and outer interfaces; and the obtained double Pickering emulsion is polymerized at a certain temperature under the action of a magnetic field, thus obtaining the porous and magnetic anisotropy microspheres. The method disclosed by the invention is simple to operate, high in efficiency and controllable in particle size. The porous and magnetic anisotropy microspheres not only have a unique porous distribution structure, but also have uniqueness on distribution of the magnetic iron oxide, and have wide application prospect in slow release of targeted medicines as well as in the field of function materials such as ordered porous membranes.

Description

technical field [0001] The invention relates to the field of porous and magnetic polymer materials, in particular to a porous magnetic anisotropic microsphere and a preparation method thereof. Background technique [0002] The preparation of porous microspheres by the emulsion template method has always been a research hotspot, but the commonly used organic small molecule emulsifiers often have certain toxicity, which is an unavoidable problem in the sustained release of drugs. However, using solid particles or colloidal particles as the stable particles of the emulsion can produce an emulsion with good stability without introducing toxic substances. This emulsion is Pickering emulsion (Pickering emulsion). [0003] Not all solid particles or colloidal particles have emulsifying properties. Only with suitable particle size, surface wettability and concentration can they have better emulsifying ability. In addition to meeting the above requirements, the stability of the emul...

Claims

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Application Information

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IPC IPC(8): C08F120/14C08F112/08C08F120/18C08F2/44C08F2/00C08K3/22H01F1/42A61K47/32
Inventor 王朝阳宁印童真
Owner SOUTH CHINA UNIV OF TECH
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