In-situ adipocyte composite inhibitor for local weight loss and body care of human bodies and preparation method thereof

Abstract

The invention discloses an in-situ adipocyte composite inhibitor for the local weight loss and body care of human bodies and a preparation method thereof. The compound (composite inhibitor) comprises the following bulk drugs: anti-NPY monoclonal antibodies, alpha-aminoethanesulfonic acid, mannitol, enol phosphatidylcholine, sodium deoxycholate, trans-10, cis-12conjugated linoleic acid, docosahexenoic acid, berberine, emodin, sodium bicarbonate and injection water. The compound of the invention can synchronously inhibit the propagation and the differentiation of preadipocytes, accelerate and promote the decomposition and the conversion of fats in mature adipocytes, effectively reduce the quantity of in-situ and newborn mature adipocytes, regulate the expression, the synthesis and the secretion of relevant adipogenic genes and adipocyte growth factors from the gene level and the like, and control the propagation and the fat synthesis of the adipocytes at the source; and, additionally, the absorption utilization rate of the compound is improved through local administration, so the compound has the rapid and efficient weight loss effect.

Description

technical field [0001] The invention relates to the field of medical cosmetic and health care products, in particular to an in situ fat cell line compound inhibitor which can be used for partial weight loss and body shaping of human body and a preparation method thereof. Background technique [0002] Obesity has always been a matter of great importance, concern and concern. Because excessive obesity will not only seriously affect human health and physiological functions and obesity metabolic syndrome (such as coronary heart disease, hypertension, diabetes, tumors and many other diseases), but also cause inconvenience to people's lives and actions and affect external appearance. The beautiful image and posture cause the patient's psychological inferiority and pain, and further lead to their psychological disorders, mental depression and decline in social adaptability, which aggravates the condition. Moreover, with the continuous improvement of social civilization, people's r...

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Problems solved by technology

However, if the apoptosis, destruction, and dissolution of adipocytes in the adipose tissue in situ cannot be resolved, and the number of adipocytes in the adipose tissue in situ is reduced, even if it can inhibit the proliferation of preadipocytes and control the increase in the number of these cells, it can also inhibit the development of preadipocytes. Differentiation and the increase of fat synthesis and volume in the cells can only achieve the purpose of controlling the aggravation of obesity, but if the number of fat cells in situ cannot be reduced, it is impossible to fundamentally achieve the purpose of local weight loss and body shaping in the true sense

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