Phenformin hydrochloride and preparation process thereof
A technology of phenformin hydrochloride and medicine, which is applied in the field of medicine, can solve the problems of repeated drug withdrawal, large side effects, and insignificant therapeutic effect, and achieve the effects of overcoming large toxic and side effects, lowering blood sugar, and improving the overall function of the body
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Embodiment 1
[0033] A compound phenformin hydrochloride pharmaceutical composition is characterized in that it is prepared from the following weight ratio raw materials,
[0034] 1 part of phenformin hydrochloride, 25 parts of astragalus, 22 parts of Chinese yam, 20 parts of herb, 15 parts of Scrophulariaceae, 10 parts of angelica, 7 parts of Radix Ophiopogon japonicus.
[0035]Wherein said phenformin hydrochloride can be purchased commercially, and the preferred preparation method is:
[0036] 1. Feeding ratio
[0037] Phenylethylamine 35.8kg
[0038] Hydrochloric acid 33kg
[0039] Dicyandiamide 25kg
[0040] 2. Production process
[0041] 2.1 Add 35.8kg of phenethylamine to a 100L reaction tank, add hydrochloric acid dropwise while stirring, keep the temperature at 45-50°C, and after about 1-1.5 hours, adjust the pH to 5, then slowly distill water, when the temperature When the temperature rises to 132-136°C and the amount of distilled water reaches 10kg at the same time, stop the ...
Embodiment 2
[0053] clinical information
[0054] Clinical Trials:
[0055] Materials and Methods: A total of 120 patients with type II diabetes mellitus were selected from the general information clinic, including 68 males and 52 females, aged 38 to 75, and were divided into two groups, 60 cases in the experimental group and 60 cases in the control group. The compound phenformin hydrochloride pharmaceutical composition prepared in Example 1 and the commercially available metformin were taken continuously for 10 days, and the clinical curative effect was observed, and other Chinese and Western medicines were stopped during the treatment.
[0056] Diagnostic criteria: Evaluate the curative effect with reference to the criteria stipulated in the "Guiding Principles of Clinical Research for the Treatment of Diabetes" in the "Guiding Principles for Clinical Research of New Chinese Medicines" formulated by the Ministry of Health in 1993. Markedly effective: After treatment, the symptoms basica...
Embodiment 3
[0061] typical embodiment
[0062] Zhang, a 55-year-old patient, has suffered from diabetes for more than 3 years. She took metformin, mepidar and other hypoglycemic drugs by mouth. Her blood sugar fluctuated from time to time, accompanied by weakness, weight loss, irritability, dry and dilute stools, lack of sleep, and thirst. But don't drink too much. The tongue is fat, with scalloped edges, dark red color, thin yellow fur, and weak pulse. After taking the medicine described in Example 1 of the present invention for one month, the dryness and thirst were relieved, and the physical strength recovered to some extent. After continuing to take it for one month, the condition was stable. The urine sugar turned negative, the fasting blood sugar was 5.6mmol / l, and the postprandial blood sugar was 6.1mmol / l. The condition was basically stable and the body returned to normal.
[0063] Qiao Yang, male, 49 years old, in the past month, suddenly thirsty, polyuria, sweet taste in the mo...
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