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Preparation method for L-pyroglutamic acid

A technology of pyroglutamic acid and glutamic acid, which is applied in the field of biopharmaceuticals and can solve the problems of difficult removal of other impurities and complicated preparation process.

Active Publication Date: 2012-07-11
BENGBU BBCA MEDICINE SCI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the above two methods is complicated, and other impurities are easy to be introduced and difficult to remove.

Method used

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  • Preparation method for L-pyroglutamic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] High temperature melting:

[0020] Put 200kg of glutenic acid (Hangzhou Xin'anjiang Monosodium Glutamate Factory) into a 500L electric heating reactor with a stirrer, when the temperature rises to 155°C, the glutaric acid melts, keep it warm for 10min, and immediately discharge the reaction solution from the discharge port of the reactor. 175kg of reaction solution was collected.

[0021] Cleaning:

[0022] Add 150L of pure water (500L storage tank) to the above reaction solution, control the temperature at 50°C and keep it warm for 20 minutes and stir until the solution is clear and then lowered to room temperature. The solution cooled to room temperature was filtered to remove solid impurities. The filtrate continued to stand at room temperature for 24h. A small amount of solid appeared and was filtered and the filtrate was collected.

[0023] Decolorization:

[0024] Add 10Kg of activated carbon to the above filtrate, decolorize at 70°C for 1 hour, and filter wh...

Embodiment 2

[0028] High temperature melting:

[0029] Put 150kg of glutenic acid into a 500L electric heating reactor with a stirrer, when the temperature rises to 160°C, the glutaric acid melts, keep it warm for 5 minutes, and immediately discharge the reaction solution from the discharge port of the reactor. 120kg of reaction solution was collected.

[0030] Cleaning:

[0031] Add 108L of pure water (500L storage tank) to the above reaction solution, control the temperature at 60° C. and keep it warm for 20 minutes and stir until the solution is clear and then lowered to room temperature. The solution cooled to room temperature was filtered to remove solid impurities. The filtrate continued to stand at room temperature for 24h. A small amount of solid appeared and was filtered and the filtrate was collected.

[0032] Decolorization:

[0033] Add 5Kg of activated carbon to the above filtrate, decolorize at 65°C for 1 hour, and filter while it is hot. The filtrate can be decolorized ...

Embodiment 3

[0037] High temperature melting:

[0038] Put 180kg of glutenic acid into a 500L electric heating reactor with a stirrer, when the temperature rises to 150°C, the glutaric acid melts, keep it warm for 15min, and immediately discharge the reaction solution from the outlet of the reactor. 155kg of reaction solution was collected.

[0039] Cleaning:

[0040] Add 132L of pure water (500L storage tank) to the above reaction solution, control the temperature at 55°C and keep it warm for 20 minutes and stir until the solution is clear and then lowered to room temperature. The solution cooled to room temperature was filtered to remove solid impurities. The filtrate continued to stand at room temperature for 24h. A small amount of solid appeared and was filtered and the filtrate was collected.

[0041] Decolorization:

[0042] Add 7Kg of activated carbon to the above filtrate, decolorize at 75°C for 1 hour, and filter while it is hot. The filtrate can be decolorized twice accordin...

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Abstract

The invention relates to a preparation method for L-pyroglutamic acid. The preparation method comprises the following steps of: melting glutamic acid serving as a raw material at a high temperature, and purifying; and concentrating and crystalizing to obtain the L-pyroglutamic acid. The method for the L-pyroglutamic acid, disclosed by the invention, is easy to operate, and has low cost and high yield.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, in particular to a preparation method of L-pyroglutamic acid. Background technique [0002] The chemical name of L-pyro glutamic acid is L-2-pyrrolidone-5-carboxylic acid. There is a chiral carbon atom in the chemical structure, so there are D-type and L-type. The chemical structural formula of L-pyroglutamic acid is as follows: [0003] [0004] L-pyroglutamic acid can be used as a biochemical reagent, mainly for the resolution of racemic amines. At present, L-pyroglutamic acid is used as a cosmetic moisturizer in the daily chemical field. [0005] The synthesis of pyroglutamic acid in the market is mainly obtained by dehydration of glutamic acid as raw material. The synthesis of L-pyroglutamic acid reported by Feng Dayan in "Chemical World" is obtained by dehydration and cyclization of glutamic acid as raw material. CN101407488B reports the chemical synthesis method of pyroglutamate al...

Claims

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Application Information

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IPC IPC(8): C07D207/28
Inventor 汪洪湖韦亚锋张亚陈文婕张昌卓陈昀赵辉
Owner BENGBU BBCA MEDICINE SCI DEV
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