Method for extracting quebrachitol from natural latex

A technology for extracting quebranol and natural rubber latex, which is applied in the field of extracting quebranol, can solve the problems of unrealized large-scale production of chiral drug raw materials, and achieve the goal of improving the level of comprehensive utilization and development, simple process steps, and improving serious pollution Effect

Inactive Publication Date: 2015-05-13
邓世明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the extraction of high-value chiral drug raw material - quebranol from natural rubber latex has not yet achieved large-scale production

Method used

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Examples

Experimental program
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Embodiment 1

[0016] Take natural rubber latex, centrifuge, coagulate and separate the remaining liquid of 5000ml, boil and evaporate to about 2000ml, filter out the sediment; Activated carbon chromatography column, fully eluted with deionized water 4 times the volume of activated carbon column, collected the eluate from the chromatography column; the eluate was evaporated and concentrated, and the concentrated solution was adsorbed, dispersed and dried by 200g of 60-100 mesh silica gel , reflux extraction with methanol for 4 times, each time for 2 hours, and combine the extracts to a total of 500ml; the methanol extract was concentrated at 55°C with a rotary evaporator under reduced pressure, the methanol was recovered, the concentrated solution was poured out, and crystals were precipitated after cooling to room temperature, and the crystals were collected. Methanol Heat to dissolve and recrystallize to obtain quebracho cortex, about 12g.

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Abstract

The invention relates to a technical process for extracting quebrachitol, which is a chiral medicinal raw material intermediate, from the processing wastewater of natural rubber, particularly to a method for extracting quebrachitol from natural latex, belonging to the field of pharmaceutical chemical engineering. The invention discloses the process steps and process parameters of the method for extracting quebrachitol from natural latex, wherein the process steps comprise centrifuging, solidifying, concentrating, filtering, decolouring, eluting, dispersing, refluxing-extracting, crystallizing and the like; large-scale production can be realized; and the comprehensive development and utilization level of the rubber industry can be remarkably improved.

Description

technical field [0001] The invention relates to a method for extracting Quebrachitol from natural rubber latex, which belongs to the field of medicine and chemical industry. Background technique [0002] Quina cortisol is L-2-methoxy inositol, which is an optically active chiral compound, and is an ideal chiral drug raw material emerging in the pharmaceutical industry, with broad application prospects. At present, quebranol has been used to synthesize aminocyclic alcohol antibiotics for the treatment of pneumonia, to prepare antibacterial preservatives and parasiticides, and pharmaceutical workers are further developing it into a series of treatments for cancer, Alzheimer's and AIDS. sex drugs. At present, chiral drugs have accounted for half of the world's pharmaceutical market. However, the research and development and production costs of optically active chiral drugs are huge, and there are few plants in nature that can biosynthesize pure optically active compounds. Qui...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C43/196C07C41/34C07C41/36C07C41/40
Inventor 邓世明杨先会汤丽昌
Owner 邓世明
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