Anti-tumor use, preparation method and composition of garlic total polysaccharide

A technology of total polysaccharide and composition is applied to the application of total garlic polysaccharide and its pharmaceutical composition in the preparation of antitumor drugs. The preparation field of total garlic polysaccharide can solve the problems of insufficient depth and comprehensiveness, and achieve the extraction rate of products. High, immune-enhancing, quality industrializable effect

Active Publication Date: 2012-07-11
金乡县力能生物科技有限公司
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the development and application of garlic polysaccharides for anti-tumor and enhancing the immune function of tumor-bearing animals in the existing technology is not deep and comprehensive enough, and it is necessary to strengthen the research of garlic polysaccharides in the field of anti-tumor prevention and garlic application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-tumor use, preparation method and composition of garlic total polysaccharide
  • Anti-tumor use, preparation method and composition of garlic total polysaccharide
  • Anti-tumor use, preparation method and composition of garlic total polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: the preparation of garlic total polysaccharide

[0058] Garlic 200kg, crushed to particles with a diameter of 0.5-1cm, double extraction once, water extraction twice, add 5 times, 4 times and 4 times of water respectively, each time for 1h, the liquid is decompressed and recovered water (temperature<80°C ), concentrate (60 DEG C relative density 1.05), add ethanol alcohol precipitation to the water concentrate, make the alcohol content reach 80% (volume ratio), leave overnight, centrifuge, get light yellow garlic total polysaccharide, the paste yield is 12.89%.

Embodiment 2

[0059] Embodiment 2: the preparation of garlic total polysaccharide

[0060] Garlic 5kg, crushed to a diameter of about 0.5cm, double extraction once, water extraction once, add 7 times and 5 times of water respectively, extract 0.5h each time, depressurize and recover water (temperature<80°C), concentrate ( 60°C (relative density: 1.08), add ethanol to the water concentrate to make the alcohol content reach 75% (volume ratio), leave it overnight, centrifuge to obtain the supernatant, pass it through a D900 resin column to obtain milky white garlic total polysaccharide, and produce a paste Rate 3.95%.

Embodiment 3

[0061] Embodiment 3: Determination of the content of garlic total polysaccharide by ultraviolet-visible spectrophotometry

[0062] 1. Instruments and reagents

[0063] 1. Instrument:

[0064] 8453 UV-Vis spectrophotometer (Agilent, USA); HW·SY11-K digital constant temperature water bath (Beijing Changfeng Instrument Company); CX-250 ultrasonic cleaning machine (Tianhai Shuanglong Medical Equipment Co., Ltd.)

[0065] 2. Reagent: 5% (weight to volume ratio) phenol solution (analytically pure, Tianjin Fuchen Chemical Reagent Factory); Concentrated sulfuric acid and 95% (volume ratio) ethanol solution (both analytically pure, Beijing Chemical Plant); D- Anhydrous glucose reference substance (for content determination, China Institute for the Control of Pharmaceutical and Biological Products, batch number: 110833-200503).

[0066] 2. Sample determination

[0067] 1. Preparation of reference solution

[0068] Accurately weigh about 12mg of anhydrous glucose reference substanc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides the application of garlic total polysaccharide to the preparation of an anti-tumor medicament, and a preparation method for the garlic total polysaccharide. Medicinal dregs obtained after garlic oil is extracted from garlic are fully used. The preparation method is low in cost, simple in operation, high in product extraction rate and controllable in quality and can realize industrial production. The invention also provides the garlic total polysaccharide prepared by the method and a medicinal composition of the garlic total polysaccharide. The garlic total polysaccharide has high anti-tumor activity and the function of enhancing immunity, is safe and nontoxic and can be prepared into an anti-tumor medicament.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of a polysaccharide, in particular to the application of the total garlic polysaccharide and its pharmaceutical composition in the preparation of antitumor drugs, and also to the preparation method of the total garlic polysaccharide. Background technique [0002] Tumor is one of the major diseases that endanger human health in today's society, and has become the second leading cause of death in the world after cardiovascular and cerebrovascular diseases. The treatment of malignant tumors generally adopts surgery, combined with radiotherapy and chemotherapy, but chemotherapy drugs have certain toxic and side effects. In contrast, traditional Chinese medicine antineoplastic drugs have unique advantages, such as dispelling pathogens, strengthening the body, or synergizing and reducing toxicity. Therefore, traditional Chinese medicine antineoplastic drugs have always been a hot s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/8962A23L1/29A61P35/00A61P35/02A23L33/00
Inventor 刘丽梅鞠大宏柏冬张立石王瑞海薛欣赵宏艳
Owner 金乡县力能生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap