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Application of SBT as inhibitor of GSK-3beta

A kind of inhibitor, aspect technology, applied in the field of application of SBT as inhibitor of GSK-3β

Inactive Publication Date: 2012-07-11
SHANGHAI RIXIN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the use of SBT for the prevention and / or treatment of AD and aging at home and abroad

Method used

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  • Application of SBT as inhibitor of GSK-3beta
  • Application of SBT as inhibitor of GSK-3beta
  • Application of SBT as inhibitor of GSK-3beta

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: prepare the SBT of different dosage forms:

[0023] Prepare SBT tablets, capsules, powders, granules, microgranules, syrups, solutions, emulsions, suspensions, chewing agents, injections (subcutaneous injections, intramuscular injections, intravenous injections, etc.) , drips, external preparations (ointments, patches, adhesives, sprays, suppositories, etc.), etc.

Embodiment 2

[0025] A drug for preventing and / or treating Alzheimer's disease and senility, consisting of SBT, with a daily dose of 500mg.

Embodiment 3

[0027] A medicine for preventing and / or treating Alzheimer's disease and aging, comprising 1000 parts by weight of SBT, 1000 parts by weight of lipoic acid, 1000 parts by weight of carnitine, 1000 parts by weight of zinc sulfate, 1000 parts by weight of coenzyme Q10, and 1000 parts by weight of vitamin B6 The parts by weight are formed by mixing 10 parts by weight of methylcobalamin and 1000 parts by weight of folic acid. The daily dose is 1000mg.

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PUM

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Abstract

The invention provides an application of SBT as an inhibitor of GSK-3beta, and particularly SBT is applicable to the prevention and treatment of alzheimer disease and senility. Currently, no research on the application of SBT to the prevention and treatment of AD and senility is reported at home and abroad. The invention firstly discloses that SBT has the effect of increasing the p-GSK-3beta level, decreasing the GSK-3beta level, and protecting nerves, and thus is applicable to the prevention and / or treatment of AD and senility.

Description

technical field [0001] The invention relates to the application of SBT in the aspect of inhibitor of GSK-3β, which can be used for preventing and treating Alzheimer's disease and aging. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment, also known as senile dementia. According to the survey, the number of AD patients in the United States reached 5.4 million in 2010, and it is expected to reach 11-16 million in 2050, while the number of AD patients in the world may exceed 30 million. As the world's largest developing country and a country that has entered an aging society, the prevalence and incidence of dementia in my country are close to those of European and American countries. A survey on the prevalence of AD in four major cities, Beijing, Shanghai, Chengdu, and Xi'an, showed that the prevalence of elderly people over the age of 65 w...

Claims

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Application Information

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IPC IPC(8): A61K31/51A61P25/28A61P39/00A61K33/30A61K31/714A61K31/519A61K31/4415A61K31/385A61K31/205A61K31/122
CPCA61K31/505A61P25/28A61P39/00
Inventor 钟春玖赵士民何银华张寰
Owner SHANGHAI RIXIN BIOTECHNOLOGY CO LTD
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