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Metronidazole ophthalmic gel and preparation method and application thereof

A metronidazole ophthalmic and ophthalmic gel technology, which is applied in the fields of emulsion delivery, sensory diseases, drug combination, etc., can solve the problem of the absence of metronidazole ophthalmic gel research and drug production reports, conjunctival sac residence time short, low curative effect, etc., to achieve the effect of highlighting substantive features, easy drug absorption, and long residence time

Inactive Publication Date: 2012-07-11
段亚东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary metronidazole eye drops have short residence time in conjunctival sac and low curative effect
At present, there are no ophthalmic pharmaceutical preparations on the domestic market that can kill Demodex mites and Acanthamoeba, and there is no report on the research and production of metronidazole ophthalmic gel.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prescription composition: metronidazole 0.75g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5g, ethylparaben 0.025 g, add water for injection to the full amount to make 100g metronidazole ophthalmic gel.

[0020] Preparation method: Dissolve metronidazole with an appropriate amount of water for injection, stir with hydroxypropyl methylcellulose, hydrogenated hard castor oil, boric acid, propylene glycol, sodium chloride, and ethylparaben respectively, and heat to dissolve completely to form Metronidazole solution; carbomer is sprinkled in water for injection, swollen into a gel solution, added to the above metronidazole solution, autoclaved, cooled, filtered, subpackaged and packaged to obtain the product.

Embodiment 2

[0022] Prescription composition: metronidazole 0.5g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5g, ethylparaben 0.025 g, add water for injection to the full amount to make 100g metronidazole ophthalmic gel.

[0023] Preparation method: with embodiment 1.

Embodiment 3

[0025] Prescription composition: metronidazole 1.0g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5g, ethylparaben 0.025 g, add water for injection to the full amount to make 100g metronidazole ophthalmic gel.

[0026] Preparation method: with embodiment 1.

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PUM

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Abstract

The invention discloses metronidazole ophthalmic gel and a preparation method and an application thereof, which belong to the technical field of medicine. Metronidazole serving as a related medicinal active ingredient is prepared into ophthalmic gel for the first time. The metronidazole ophthalmic gel is applied to prevention and treatment of blepharitis ciliaris, hordeolum and conjunctivitis caused by worm acarus infection, and a dry eye syndrome caused by meibomian gland dysfunction, and is applied to prevention and treatment of infection of acanthamoeba protozoan and anaerobic bacteria in the wearing process of corneal contact lenses. The metronidazole ophthalmic gel consists of metronidazole and a pharmaceutically-acceptable vector, and the using amount of metronidazole in every 100g of the metronidazole ophthalmic gel is 0.1-3.0g by weight.

Description

technical field [0001] The invention relates to metronidazole, an active ingredient of medicine, which is made into ophthalmic gel dosage form for the first time, and is applied to the prevention and treatment of ocular demodex mite, acanthamoeba and anaerobic bacteria infection. Background technique [0002] Intractable blepharitis, hordeolum, conjunctivitis, and dry eye caused by meibomian gland dysfunction (MGD) have recently been confirmed to be related to the infection of worms and mites (International Survey of Ophthalmology, 2007, 3: 149 ; Clinical Ophthalmology, 2010, 4:358). Mu Jian detected 90% of the demodectic mites in 91 patients with blepharitis (Journal of Clinical Ophthalmology, 2010, 4:358). Gao has a detection rate of 100% for Demodex mites on the eyelid (Invest ophthalmol vis sci, 2005, 46: 3089). Acanthamoeba keratitis is a severe blinding eye disease caused by Acanthamoeba infection. 75% of patients have a history of wearing contact lenses, which can c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4164A61P31/04A61P33/02A61P33/14A61P27/02
Inventor 段亚东
Owner 段亚东
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