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Anthraquinone derivatives and preparation method and application thereof

A derivative, anthraquinone technology, applied in the field of anthraquinone derivatives, can solve the problems of obtaining anti-porcine reproductive and respiratory syndrome virus, no antiviral drugs, and no antiviral drugs, so as to inhibit pig reproduction and respiratory Syndrome virus, strong antiviral activity, effect without resource constraints

Active Publication Date: 2016-03-02
OCEAN UNIV OF CHINA
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  • Abstract
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  • Claims
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Problems solved by technology

Due to the particularity of the marine environment and the unique functions of microorganisms in the ecosystem, marine fungi can produce metabolites that terrestrial fungi cannot produce. However, so far, no anti-porcine reproductive and respiratory syndrome virus has been obtained from fungi. (PRRSV) active compound, there is no related antiviral drug on the market

Method used

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  • Anthraquinone derivatives and preparation method and application thereof
  • Anthraquinone derivatives and preparation method and application thereof
  • Anthraquinone derivatives and preparation method and application thereof

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Embodiment Construction

[0009] In preparing the compounds of the present invention, the following steps are taken:

[0010] (1) Carry out strain culture to marine fungus Alternariasp. (ZJ-2008003) in strain culture medium earlier, used strain culture medium contains glucose 2.0% (percentage by weight, the same below), potato 20.0%, agar 1.5% , coarse sea salt 3.0%, and the rest is water, which is made into a test tube slope during use, and the above-mentioned fungal strains are cultivated at 28° C. for 5 days.

[0011] The strain culture medium contains 0.1%-5.0% of glucose (percentage by weight, the same below), 5.0%-40.0% of potato, 0.1%-3.0% of agar, 0.05%-5.0% of coarse sea salt, and the rest is water. The temperature is 15-35°C, and the cultivation time is 3-10 days.

[0012] (2) The fungal strains obtained from the above culture are fermented, and the fermentation medium used contains 2.0% glucose, 20.0% potato, 3.0% coarse sea salt, and the rest is water. The fungal strains were grown at 28°...

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Abstract

The invention relates to an anthraquinone derivative, a preparation method and application thereof. During preparation, entomopathogenic fungi in soft coral Alternaria sp. (ZJ-2008003) is first placed in a strain culturing medium for strain culturing and then placed in a fermentation culturing medium for fermentation culturing, obtained fermentation liquor is filtered, thalli are removed to obtain filtrate, and the filtrate is extracted through ethyl acetate; after extract liquor is concentrated, silicagel column chromatography, sephadex LH-20 gel column chromatography and half-preparation of high performance liquid chromatography preparation are conducted, obtained eluent is concentrated, and clear crystals are obtained, namely, the compound of tetrahydroaltersolanols C-E; pink powder is obtained, namely, the compound of tetrahydroaltersolanol F. The anthraquinone derivative originating from marine fungi has strong antiviral effect, can effectively restrain porcine reproductive and respiratory syndrome virus (PRRSV), can be used as antiviral drug, and has broad application prospects due to the fact that raw materials can be produced in a large scale.

Description

technical field [0001] The invention relates to an anthraquinone derivative extracted and separated from the fermentation broth of marine endophytic fungi, a preparation method thereof and an application as an antiviral drug. Background technique [0002] Since penicillin was prepared from fungi in 1929, fungal metabolites have become a rich source of drugs, and the vast majority of clinically used antibiotics are derived from fungi and bacteria. The metabolites of fungi also have other medicinal value, such as anti-tumor, treatment of cardiovascular diseases, enzyme inhibitors, etc. Due to the particularity of the marine environment and the unique functions of microorganisms in the ecosystem, marine fungi can produce metabolites that terrestrial fungi cannot produce. However, so far, no anti-porcine reproductive and respiratory syndrome virus has been obtained from fungi. (PRRSV) active compound, there is no relevant antiviral drug on the market yet. Contents of the inve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/747C07C69/21C12P7/26C12P7/62A61K31/122A61K31/222A61P31/12C12R1/645
Inventor 王长云邵长伦郑彩娟
Owner OCEAN UNIV OF CHINA
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