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Traditional Chinese medicine composition for preventing insulin resistance and related metabolic syndrome thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as weight gain

Active Publication Date: 2012-07-04
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main side effects of this class of drugs are edema and weight gain

Method used

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  • Traditional Chinese medicine composition for preventing insulin resistance and related metabolic syndrome thereof
  • Traditional Chinese medicine composition for preventing insulin resistance and related metabolic syndrome thereof
  • Traditional Chinese medicine composition for preventing insulin resistance and related metabolic syndrome thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Preparation of Rhodiola rosea extract

[0070]The preparation of the total extract of Rhodiola rosea: adopt the rhizome of dried Rhodiola rosea as the original drug, grind and extract 3 times with 70% ethanol backflow, each dosage is 8 times of the weight of the original drug, and the extraction time is 3 times each time. hours, the extracts were combined and filtered, and the filtrate was concentrated under reduced pressure to recover ethanol until there was no alcohol smell, and the extract was obtained. The density of the extract was adjusted to 1.16, and 5 times the amount of water was added for water precipitation. The precipitate is filtered, and the filtrate is concentrated under reduced pressure until it has no alcohol smell to obtain the total extract of Rhodiola rosea, which is freeze-dried to obtain the total extract of Rhodiola rosea.

[0071] Preparation of Rhodiola grandiflora extract: After the total extract of Rhodiola rosea is dispersed in wat...

Embodiment 2

[0072] Example 2 Preparation of Rhodiola angustifolia Extract

[0073] The preparation of the total extract of Rhodiola angustifolia: adopt the dried rhizome of Rhodiola angustifolia as the original drug, grind and extract 3 times with 80% ethanol under reflux, each dosage is 10 times of the weight of the original drug, and the extraction time is 2 hours each time, Combine the extracts and filter, concentrate the filtrate under reduced pressure to recover ethanol until there is no alcohol smell, and obtain the extract, adjust the density of the extract to 1.17, add 8 times the amount of water for water precipitation, stand at 5°C for 72 hours, and filter the precipitate , the filtrate was concentrated under reduced pressure until it had no alcohol smell, and the total extract of Rhodiola angustifolia was obtained, and the total extract of Rhodiola angustifolia was obtained after freeze-drying.

[0074] Preparation of Rhodiola angustifolia extract: After the total extract of Rh...

Embodiment 3

[0077] Preparation of the total extract of Cordyceps militaris: the dry product of Cordyceps militaris is reflux extracted with 80% ethanol, the number of extractions is three times, each time the dosage is 10 times the weight of the original drug, the extraction time is 2 hours each time, and the extract is filtered to remove the residue Finally, the filtrate was concentrated under reduced pressure to obtain the total extract of Cordyceps militaris, and was freeze-dried to obtain the total extract of Cordyceps militaris.

[0078] Preparation of Cordyceps militaris extract: The total extract of Cordyceps militaris is subjected to macroporous resin separation, gradient elution with pure water-95% ethanol system, and is divided into 3 parts, namely water part, 30% part and 95% part, 30% of which is concentrated under reduced pressure and freeze-dried to obtain the Cordyceps militaris extract.

[0079] Inspection of the Cordyceps militaris extract: the content of the cordycepin i...

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Abstract

The invention relates to a traditional Chinese medicine composition taking Rhodiola rosea extract, cordyceps militaris extract and rhein as the major components, a preparation method and a medical composition of the traditional Chinese composition as well as applications of the traditional Chinese medicine composition and medical composition in preventing and / or treating insulin resistance and related metabolic syndrome thereof.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition mainly composed of Rhodiola rosea extract, Cordyceps militaris extract and rhein, its preparation method, its pharmaceutical composition and their effects in preventing and / or treating insulin Use in resistance and its associated metabolic syndrome. Background technique [0002] Insulin resistance refers to the decreased sensitivity and / or responsiveness of the body to insulin, which is the main pathophysiological basis of metabolic syndrome, and is related to impaired glucose tolerance, type 2 diabetes and its complications, obesity, dyslipidemia, non- A series of chronic clinical abnormalities of metabolic syndrome such as alcoholic fatty liver and coronary heart disease are closely related. Metabolic Syndrome belongs to TCM Diabetes and is complicated by dizziness, chest obstruction, obesity, arthralgia and other symptoms. It has...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61P5/50A61P3/04A61P3/06A61P1/16A61K31/192
Inventor 叶菲张培成田金英杨桠楠张晓琳冯子明陈玲姜建双韩静刘照振李娟陈钟付健阳
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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