Application of physically-modified cobra venom in preparation of medicament for treating pulmonary fibrosis
A cobra snake venom, physical modification technology, applied in the field of cobra snake venom, preparation of drugs for the treatment of lung inflammation and pulmonary fibrosis, can solve the problems that the effect of lung inflammation has not been reported yet, achieve good treatment of pulmonary fibrosis, reduce synthesis , the effect of large effective range
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[0033] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions adopted in the examples can be further adjusted according to the conditions of specific experiments, and the implementation conditions not indicated are usually the conditions in routine experiments.
[0034] The animal pharmacodynamic experiment of the Chinese cobra venom after embodiment physical modification
[0035] (1) Acute lung injury experiment induced by lipopolysaccharide in mice
[0036] Lipopolysaccharide (LPS) is a component in the cell wall of Gram-negative bacteria, which can cause various inflammatory reactions in the body. A single administration of 5 mg / kg LPS can make a mouse model of acute lung injury. Kunming mice were randomly divided into 5 groups (n=10) of half and half female, body w...
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