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Concentrating device and concentrating method of acarbose destaining solution

A technology of acarbose and decolorization solution, which is applied in the concentration equipment and concentration field of acarbose decolorization solution, which can solve the problems of low efficiency, time-consuming and energy-consuming, etc., so as to increase the processing capacity, speed up speed and efficiency, and speed up production The effect of the process

Inactive Publication Date: 2012-06-27
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to overcome the defects of low efficiency, time-consuming and energy-consuming concentrating equipment and concentrating methods used for acarbose decolorization solution in the prior art, and provide a kind of concentrating equipment for acarbose decolorization solution with high efficiency concentration and energy saving and enrichment method

Method used

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  • Concentrating device and concentrating method of acarbose destaining solution
  • Concentrating device and concentrating method of acarbose destaining solution
  • Concentrating device and concentrating method of acarbose destaining solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Output about 7000L of acarbose decolorization solution from the material tank, pressurize it to 0.40MPa through the pre-pressurization pump, and then input it to the high-pressure plunger pump through the stainless steel pipeline; adjust the plunger pump so that the pressure of the decolorization solution reaches 4.0MPa, with a flow rate of 5.5 tons / hour, it is input into a disc membrane (the molecular weight cut-off of the membrane is 150, and the material is polyamide) for concentration. The water in the decolorization solution enters the permeate collector through the membrane of the disc membrane and leaks out from the permeate outlet, while the acarbose that cannot pass through the membrane of the disc membrane flows into another storage tank , forming a concentrate. The concentration was completed in about 6 hours, and about 850 L of the concentrated solution in the form of a clear and transparent liquid was obtained, and the tested titer was about 260,000 μg / mL; ...

Embodiment 2

[0080] Output about 7000L of acarbose decolorization liquid from the material tank, pressurize it to 0.50MPa through the pre-pressurization pump, and then input it to the high-pressure plunger pump through stainless steel pipes and flexible pipes; adjust the plunger pump to make the decolorization The pressure of the liquid reaches 7.0MPa, and it is fed into the disc membrane (the molecular weight cut-off of the membrane is 380 and the material is polyamide) through flexible pipes and stainless steel pipes at a flow rate of 5.0 tons / hour for concentration. The water in the decolorization solution enters the permeate collector through the membrane of the disc membrane and leaks out from the permeate outlet, while the acarbose that cannot pass through the membrane of the disc membrane flows into another storage tank , forming a concentrate. Concentration was completed in about 7 hours, and about 700 L of the concentrated solution in the form of a clear and transparent liquid was...

Embodiment 3

[0082] About 7000L of acarbose decolorization liquid is output from the material tank, pressurized to 0.45MPa by the pre-pressurization pump, and then input to the filter device with a pore size of 15μm, and the filtrate is input to the high-pressure plunger pump through stainless steel pipes and flexible pipes ; Regulate the plunger pump so that the pressure of the decolorizing solution reaches 5.0MPa, and enter the disc membrane (wherein the molecular weight cut-off of the diaphragm is 200, and the material is polyethersulfone ) to concentrate. The water in the decolorization solution enters the permeate collector through the membrane of the disc membrane and leaks out from the permeate outlet, while the acarbose that cannot pass through the membrane of the disc membrane flows into another storage tank , forming a concentrate. Concentration was completed in about 6.5 hours, and about 800 L of the concentrated solution in the form of a clear and transparent liquid was obtain...

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Abstract

The invention relates to a concentration device of acarbose destaining solution, which comprises a material tank, a pre-pressurizing device, a pressurizing device and a film device which are connected in sequence by pipelines, wherein the film device is a coil type film. The invention also provides a concentrating method of the acarbose destaining solution. The concentration device and the concentration method can be used in the mass industrialized production, so that the concentration valence of the acarbose destaining solution can be obviously improved, the concentration time of the acarbose destaining solution can be obviously shortened, the production progress can be quickened, the processing amount can be greatly improved, and the speed and the efficiency of the follow-up spray drying can be quickened.

Description

technical field [0001] The invention relates to a production equipment and a production method of acarbose. Specifically, the present invention relates to a kind of concentrating equipment and concentrating method of acarbose decolorization liquid. Background technique [0002] Acarbose (Acarbose), molecular formula: C 25 h 43 NO 18 ;Chemical name: O-4,6-dideoxy-4-[(1S,4R,5S,6S)4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexenyl- 1-Amino]-a-D-glucopyranosyl-(1→4)-O-a-D-glucopyranosyl-(1→4)-D-glucopyranose, a metabolite produced by Actinoplanes sp. , mainly for the treatment of type II diabetes. [0003] [0004] The chemical structure of acarbose [0005] In the prior art, the production process of acarbose is generally as follows: after acarbose is produced by fermentation and placed in a tank, the fermentation liquid is subjected to solid-liquid separation, the obtained solution is extracted and purified and decolorized, and the decolorized solution is concentrated ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/00B01D63/08C07H15/203C07H1/06
Inventor 何志勇周鲁谨黄建平周用松涂应君
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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