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Common threewingnut root capsules and application thereof

A technology of tripterygium wilfordii and capsules, applied in the field of traditional Chinese medicine, can solve the problems of a wide variety of drugs for hair loss and poor curative effect, and achieve the effects of good curative effect and high treatment efficiency.

Active Publication Date: 2012-06-27
HUNAN QIANJIN XIELI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention solves the technical problem that there are many kinds of medicines for treating hair loss and poor curative effect in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] The invention provides a kind of preparation method of tripterygium wilfordii capsule, comprises the following steps:

[0015] A, use the peeled root of Tripterygium wilfordii as raw material medicinal material, extract with ethanol, obtain extracting solution;

[0016] B. Concentrating the extract for the first time to obtain a concentrated solution for the first time; then filtering the concentrated solution for the first time, extracting the filtrate with chloroform, collecting the chloroform layer and concentrating for the second time to obtain a concentrated solution for the second time;

[0017] C, passing the concentrated solution for the second time through a silica gel column, using chloroform-ethanol solution as an eluent for eluting, collecting the eluent, and concentrating the eluent for the third time to obtain a concentrated solution for the third time;

[0018] D. Dry and pulverize the third concentrate, add pharmaceutically acceptable adjuvants, granulat...

Embodiment 1

[0038] Use the root xylem of Tripterygium wilfordii to remove the split bark as raw material 30kg, extract with 330L of ethanol aqueous solution with ethanol volume content of 70%, concentrate the extract to about 30L, filter, add 1.5 times the volume of chloroform to the filtrate for the first extraction , collect the chloroform layer for later use, followed by 1.2 times the volume of chloroform for secondary extraction, and 1 times the volume of chloroform for three extractions; collect all the extracts, concentrate to about 30L, and then pass through a silica gel column, using 1% chloroform volume percentage The chloroform-ethanol solution was eluted for 2 days, the chloroform-ethanol solution with a volume percentage of 2% was used for elution for 3 days, the chloroform-ethanol solution with a volume percentage content of 3% was used for 5 days, and the chloroform volume percentage was used for 5 days. Elute with 4% chloroform-ethanol for 2 days, and use chloroform with a v...

Embodiment 2

[0043] Patient 1, suffered from seborrheic alopecia with progressive hair loss until baldness. After taking the Tripterygium wilfordii capsule S1 provided in Example 1, from the second course of treatment, the bald head begins to grow fine and velvety new hair, which gradually becomes black and dense after this.

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Abstract

The invention provides a method for preparing common threewingnut root capsules, the common threewingnut root capsules prepared by the method, and application of the common threewingnut root capsules to a medicine for treating alopecia. The content of an effective pharmaceutical ingredient in the common threewingnut root capsules is higher; and the common threewingnut root capsules have a good therapeutic effect of preventing and treating alopecia, and the response rate reaches over 86.67 percent.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to tripterygium wilfordii capsules and applications thereof. Background technique [0002] Alopecia is a common disease of human beings, generally divided into four categories: seborrheic alopecia, neurogenic alopecia, autoimmune alopecia and cicatricial alopecia, the most common of which is seborrheic alopecia, accounting for more than 92% of hair loss types. Seborrheic alopecia is mainly male, and the number of female patients also has a tendency to increase in recent years, and there are more mental workers than manual workers. It has been clinically proven that seborrheic alopecia may be related to the endocrine function of the human body (mainly male hormones), mental state, heredity and certain drug factors. Nervous alopecia, also known as alopecia areata (commonly known as ghost shaved head), is caused by excessive mental stress caused by ex...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61K9/48A61P17/14
Inventor 钟林波王洪锋申利建肖仕杰徐彬滨
Owner HUNAN QIANJIN XIELI PHARMA CO LTD
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