Broad spectrum and efficient composite antibacterial agent and preparation method thereof

Abstract

The invention discloses a broad spectrum and efficient composite antibacterial agent and a preparation method thereof. The preparation method comprises the following steps of: taking cefoperazone or physiologically-acceptable salt thereof, cefradine or physiologically-acceptable salt thereof, sulbactam or physiologically-acceptable salt thereof as active ingredients; adding acceptable carriers orminor ingredients; and adopting a certain preparation technology to prepare into various clinically applicable preparations. Compared with other antibacterial agents, according to the antibacterial agent disclosed by the invention, the antibacterial activity against G+ bacteria is 2-8 times of that of the traditional cephalosporin antibacterial agent, and the antibacterial activity against G-bacteria is 2-4 times of that of the traditional cephalosporin antibacterial agent and is 2.5-10 times of other traditional antibacterial agents. The antibacterial agent can overcome the defect of drug resistance of bacteria caused by unreasonable application of the clinical antibacterial drug, and has obvious advantages showed by wide antibacterial spectrum when being used for treating pathogen infection and infection with unclear sensitivity condition, in particular severe infections or mixed infections caused by fungi. The preparation cost of the broad spectrum and efficient composite antibacterial agent is economical, the preparation method is simple and easy to operate, and the preparation technology is environmentally-friendly.

Description

technical field [0001] The invention belongs to the technical field of biomedical antibacterial drugs, and in particular relates to a novel broad-spectrum high-efficiency compound antibacterial drug and a preparation method thereof. Background technique [0002] Anti-infectives are divided into anti-bacterial, anti-fungal, anti-viral, anti-tuberculosis and anti-parasitic drugs. Antibiotics include antifungals and antibacterials. According to different chemical structures, antibacterial drugs are divided into penicillins (containing β-lactam structure), cephalosporins (containing β-lactam structure), aminoglycosides, macrolides, tetracyclines, and quinolones , Sulfonamides, etc. Among all antibacterial drugs, cephalosporins are popular in the market due to their definite curative effect and good antibacterial effect, accounting for more than 40% of the market share. [0003] Cefoperazone is a third-generation semi-synthetic cephalosporin antibiotic that mainly inhibits the...

AI Technical Summary

Problems solved by technology

The concentration of 2μg / ml has a strong inhibitory effect on Richmond-Syks II, III, IV and V type β-lactamases, but has no effect on type I β-lactamases

Although this type of preparation can appropriately enhance the antibacterial activity of the original antibacterial drug, the problem of its narrow antibacterial spectrum still cannot be solved.

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