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Multi-cell co-culture apparatus used in simulated weightless environment

A technology of simulating weightlessness and co-cultivation, applied in tissue cell/virus culture devices, biochemical instruments, biochemical equipment and methods, etc., to achieve accurate reflection, high cell yield, and easy operation

Inactive Publication Date: 2013-05-15
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the deficiency of a single type of cell research, the present invention provides a large-sample, easy-to-operate multi-cell joint culture simulated weightlessness device

Method used

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  • Multi-cell co-culture apparatus used in simulated weightless environment
  • Multi-cell co-culture apparatus used in simulated weightless environment

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Embodiment Construction

[0011] exist figure 1 and figure 2 Among them, the clamping piece (3) is a rigid material, which is divided into two pages, the upper and lower pages, which are in the shape of a hollow "mouth" and connected by an axis. Fixed between two pages. The cross-shaped support (5) is a rigid structure, and each of the four ends of the cross-shaped support (5) has two slide grooves, and the clamping piece (3) fixed with the semi-permeable membrane (4) can be vertically inserted into the cross-shaped support (5 ) and fixed to form a sample rack, each cross-shaped support (5) can insert up to four clamping pieces (3), so as to realize mass culture of cells. The culture bottle screw cap (1) and the culture bottle body (2) are both transparent polystyrene injection molding, the culture bottle body (2) is hollow cylindrical, the upper end of the cylinder is open and has external threads, the lower end is airtight, and the culture bottle screw cap ( 1) It has an internal thread, which ca...

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Abstract

The invention provides a multi-cell co-culture apparatus used for research of simulated weightlessness. The apparatus comprises a culture bottle body, a culture bottle spiral cover, a semi-permeable membrane, a retaining piece and a cross-shaped support, wherein, the semi-permeable membrane, the retaining piece and the cross-shaped support are used for culturing cells and the culture bottle body,and the culture bottle spiral cover compose a multi-cell co-culture bottle and enable butt joint between the multi-cell co-culture apparatus and a cell simulated weightless device to be realized. Theapparatus can be used for culture of a single kind of cells in a simulated weightless environment and for co-culture of two or more kinds of cells in a simulated weightless environment, fully takes influence of contact among cells and cell communication into consideration, can maximumly meet requirements for multi-cell co-culture in a simulated weightless environment, enables the disadvantage that conventional simulated weightless devices can only culture a single kind of cells to be overcome and is simple to operate and repeatedly usable.

Description

Technical field [0001] The invention relates to a multi-cell co-cultivation device in a simulated weightless environment. Background technique [0002] In vivo, the regulation of physiological functions of the body is not accomplished by a single type of cells in isolation, but by a complex regulatory network composed of multiple cells. At the same time, due to the interaction of cytokines secreted by cells and the communication between adjacent cells, the functions of cells in different tissues also affect each other. Therefore, the result obtained from the study on the isolation of a cell cannot fully reflect the functional state of the cell in vivo, and even obtain a result that is contradictory to the cell in vivo. However, the current co-cultivation techniques for multi-cells are all designed based on conventional culture conditions, and there is a lack of a multi-cell co-culture device in a simulated weightless environment. At present, due to the limitation of the de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00
Inventor 孙喜庆王永春张舒
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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