Novel synthesis technology of 7-dehydrocholesterol
A dehydrocholesterol, new synthesis technology, applied in the direction of steroids, organic chemistry, etc., can solve the problems of many production steps, low efficiency, many side reactions, etc., and achieve significant economic and social benefits.
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[0028] 1 Esterification reaction:
[0029] Cholesterol + Benzoyl Chloride → Cholesterol Benzoate
[0030] The synthesis of cholesteryl benzoate is carried out in two steps, one is the synthesis of benzoyl chloride, and the other is the synthesis of cholesteryl benzoate with benzoyl chloride and cholesterol as raw materials. The specific implementation plan is as follows:
[0031] React freshly steamed thionyl chloride with benzoic acid at room temperature at 50±5°C for 1 hour (the molar ratio of thionyl chloride to benzoic acid is 1.05:1), then raise the temperature to 90°C for 2 hours. Excessive thionyl chloride was distilled off at normal pressure, and then benzoyl chloride was distilled off under reduced pressure as the raw material for the next reaction.
[0032] Dissolve cholesterol in dry benzene, add pyridine [W cholesterol (g): V benzene (ml): V pyridine (ml) = 1:4:1], then add a certain amount of benzoyl chloride, and react at room temperature 15 minutes, then slow...
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