Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Crystallization treatment process of paracetamol acylation material liquid

A technology of acetaminophen acylation material and crystallization treatment, which is applied in the field of crystallization treatment process, can solve the problems of reducing the service life of equipment, the growth of acylation tank, and the scrapping of crystallization tank, so as to reduce the generation of powder material, solve the problem of porcelain explosion and Agglomeration, prolonging the service life effect

Active Publication Date: 2012-04-11
JIHENG PHARMA HENGSHUI CITY
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the production process of acetaminophen, after the acylation and distilling of p-aminophenol and glacial acetic acid, although it is possible to directly carry out cooling and crystallization in the acylation tank, and then centrifuge, but if that takes up the acyl The time for the tank will increase, which will affect the acylation reaction of the next batch of materials. In order to speed up the material circulation process and increase the output, two tanks are selected for acylation and crystallization respectively.
That is, in order not to occupy the resources of the acylation tank, after the acylation reaction and the acid steaming process are completed, the feed liquid (hereinafter referred to as the acylation feed liquid) obtained after the completion of the acylation acid steaming process is put into another enamel reaction tank (also called crystallization tank) to carry out the crystallization reaction, during this reaction process, since the temperature of the acylation feed liquid reaches 130°C, and the temperature of the crystallization tank is relatively low, if the high-temperature acylation feed liquid meets the wall of the crystallization tank with a large temperature difference or At the bottom, there will be a phenomenon that the acylation feed liquid will agglomerate on the wall or bottom of the crystallization tank due to chilling, resulting in that the overall crystal form of the product does not meet the requirements, and the wall or bottom of the crystallization tank will also be damaged due to severe thermal shock. It is easy to appear the phenomenon of broken porcelain, thereby reducing the service life of the equipment. In the place where broken porcelain occurs, the acid contained in the acylation liquid will soak into the broken porcelain point and corrode the crystallization tank (iron enamel tank). Timely discovery and repair of the broken porcelain, the tank body at the broken porcelain will be corroded and cause the acylation material liquid placed in it to seep out or the circulating medium in the jacket enters the acylation material liquid of the crystallization tank, affecting The quality of the crystallization material, if it is more serious, the crystallization tank will be scrapped

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0022] As the first embodiment of the present invention, its technical gist is exactly to increase the temperature of the crystallization vessel before the acylation feed liquid is put into the crystallization vessel (in actual production, the crystallization tank or the crystallization kettle is often used as the crystallization vessel).

[0023] In order to avoid the adverse effects caused by the excessive temperature difference between the acylation feed liquid and the crystallization container, considering that the temperature of the acylation feed liquid is about 130-140°C, the crystallization container is preheated to about 60-80°C, and then the acylation feed liquid is Put the chemical material into the crystallization container for cooling and crystallization.

[0024] The reason for choosing to heat the temperature of the crystallization vessel to 60-80°C is due to the following considerations: since the critical temperature at which the acylation feed liquid begins to...

Embodiment approach 2

[0033] Although in the above-mentioned Embodiment 1, the tank temperature of the crystallization container has generally reached about 60-80° C. by preheating, the temperature gap with the acylation feed liquid has narrowed down a lot, and the effect of the temperature difference on the crystallization form of the feed liquid and the crystallization container has been effectively alleviated. The destruction of the enamel, but it is still possible to bring adverse effects, this is because the steam used for preheating enters the space of the jacket from the upper part of the jacket set outside the crystallization vessel, the heating of the whole tank is not uniform, and the bottom of the tank The temperature may not reach 60-80° C., which may cause problems similar to those mentioned in the background art in the subsequent crystallization reaction.

[0034]Since the temperature of the acylation material is as high as 130-140°C, and the temperature at the bottom of the crystalliz...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
critical temperatureaaaaaaaaaa
Login to View More

Abstract

The invention relates to a crystallization treatment process of paracetamol acylation material liquid, which is characterized in that the process comprises the following steps of: a preheating step for preheating a crystallization container; and a crystallization treatment step for introducing the acylation material liquid into the crystallization container and performing crystallization treatment of the acylation material liquid. Through preheating the crystallization container to a specified temperature, the impact to the bottom of the crystallization container caused by the material liquid of the high-temperature acylation material is effectively avoided; the generation of phenomena of porcelain crack and caking is solved; the service life of the equipment is prolonged; the crystal form of the crystallized material is protected favorably; the generation of powder material is reduced; and the product quality is improved.

Description

technical field [0001] The invention relates to a crystallization treatment process, in particular to a crystallization treatment process of an acylation feed solution in the production process of acetaminophen (that is, a crystallization treatment process of acetaminophen acylation feed solution). Background technique [0002] After the p-aminophenol and glacial acetic acid are batched in the batching container, they are put into the acylation kettle and acylated at 140°C. During the acylation process, water will evaporate, and a part of acetic acid will be brought out when the water evaporates (that is, the following steam acid), the acylated material needs to be crystallized after the acid distillation is completed. [0003] At present, in the production process of acetaminophen, after the acylation and distilling of p-aminophenol and glacial acetic acid, although it is possible to directly carry out cooling and crystallization in the acylation tank, and then centrifuge, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/25C07C231/02C07C231/24
Inventor 徐亚威刘晓莲蔡颂公辛秀彪马胜义贾树红张志强陈剑芳刘向军姚芸
Owner JIHENG PHARMA HENGSHUI CITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products