Crystallization treatment process of paracetamol acylation material liquid
A technology of acetaminophen acylation material and crystallization treatment, which is applied in the field of crystallization treatment process, can solve the problems of reducing the service life of equipment, the growth of acylation tank, and the scrapping of crystallization tank, so as to reduce the generation of powder material, solve the problem of porcelain explosion and Agglomeration, prolonging the service life effect
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Embodiment approach 1
[0022] As the first embodiment of the present invention, its technical gist is exactly to increase the temperature of the crystallization vessel before the acylation feed liquid is put into the crystallization vessel (in actual production, the crystallization tank or the crystallization kettle is often used as the crystallization vessel).
[0023] In order to avoid the adverse effects caused by the excessive temperature difference between the acylation feed liquid and the crystallization container, considering that the temperature of the acylation feed liquid is about 130-140°C, the crystallization container is preheated to about 60-80°C, and then the acylation feed liquid is Put the chemical material into the crystallization container for cooling and crystallization.
[0024] The reason for choosing to heat the temperature of the crystallization vessel to 60-80°C is due to the following considerations: since the critical temperature at which the acylation feed liquid begins to...
Embodiment approach 2
[0033] Although in the above-mentioned Embodiment 1, the tank temperature of the crystallization container has generally reached about 60-80° C. by preheating, the temperature gap with the acylation feed liquid has narrowed down a lot, and the effect of the temperature difference on the crystallization form of the feed liquid and the crystallization container has been effectively alleviated. The destruction of the enamel, but it is still possible to bring adverse effects, this is because the steam used for preheating enters the space of the jacket from the upper part of the jacket set outside the crystallization vessel, the heating of the whole tank is not uniform, and the bottom of the tank The temperature may not reach 60-80° C., which may cause problems similar to those mentioned in the background art in the subsequent crystallization reaction.
[0034]Since the temperature of the acylation material is as high as 130-140°C, and the temperature at the bottom of the crystalliz...
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