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Preparation method of cholagogic tablet

A gallbladder tablet and extraction technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, active ingredients of sulfur/selenium/tellurium, etc., can solve the problems of patients with large daily dosage, backwardness, and many impurities, and achieve reduction in dosage volume effect

Inactive Publication Date: 2012-04-04
JIANGSU KANGHENG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the preparation of Lidan tablets adopts the method of decocting in water, the process is rough and backward, and there are many impurities, which leads to excessive daily dosage of patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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  • Preparation method of cholagogic tablet
  • Preparation method of cholagogic tablet
  • Preparation method of cholagogic tablet

Examples

Experimental program
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Effect test

Embodiment 1

[0086] Take 58g of rhubarb, crush it, add 0.6L of 65% ethanol, put it into a microwave extraction device for microwave extraction, extraction power is 300W, extract twice, each time for 3 minutes, combine the extracts, recover ethanol under reduced pressure and concentrate, add to D101 On a macroporous adsorption resin column, elute with 30% ethanol, collect 4 times the column volume eluate, then elute with 60% ethanol, collect 4 times the column volume eluate, combine with the aforementioned eluate, and depressurize Recover ethanol, concentrate and dry to obtain rhubarb extract, and set aside; take 58g of desmodium and 58g of honeysuckle, crush them, add 1.2L of water, put them into a microwave extraction device for microwave extraction, extraction power 500W, extraction 2 times, each time 5 Minutes, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 70% ethanol, collect 5 times the column volume eluate, recover ethanol under red...

Embodiment 2

[0093] Take 58g of rhubarb, crush it, add 0.6L of 65% ethanol, put it into a microwave extraction device for microwave extraction, extraction power 600W, extract twice, 10 minutes each time, combine the extracts, recover ethanol under reduced pressure and concentrate, add to D101 On a macroporous adsorption resin column, elute with 30% ethanol, collect 4 times the column volume eluate, then elute with 60% ethanol, collect 4 times the column volume eluate, combine with the aforementioned eluate, and depressurize Recover ethanol, concentrate and dry to obtain rhubarb extract, and set aside; take 58g of desmodium and 58g of honeysuckle, crush them, add 1.2L of water, put them into a microwave extraction device for microwave extraction, extraction power 500W, extraction 2 times, each time 5 Minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 70% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced press...

Embodiment 3

[0100] Take 58g of rhubarb, crush it, add 0.6L of 65% ethanol, put it into a microwave extraction device for microwave extraction, extraction power is 400W, extract twice, 6 minutes each time, combine the extracts, recover ethanol under reduced pressure and concentrate, add to D101 On a macroporous adsorption resin column, elute with 30% ethanol, collect 4 times the column volume eluate, then elute with 60% ethanol, collect 4 times the column volume eluate, combine with the aforementioned eluate, and depressurize Recover ethanol, concentrate and dry to obtain rhubarb extract, and set aside; take 58g of Desmodium and 58g of honeysuckle, grind them, add 1.2L of water, put them into a microwave extraction device for microwave extraction, extraction power 500W, extraction 2 times, each time 5 Minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 70% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pre...

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Abstract

The invention relates to a preparation method of a cholagogic tablet, which comprises the following steps that: rhubarb is taken and extracted by microwave and is purified by macroporous resin columns to obtain the rhubarb extract; desmodium and honeysuckle are taken and extracted by microwave and are purified by macroporous adsorption resin and ion exchange resin to obtain desmodium-honeysuckle extract; costus root, rhizoma anemarrhenae, dyers woad leaves, radix bupleuri, root of herbaceous peony, radix scutellariae and Herba Artemisiae Capillaris are taken, pulverized and are extracted under a carbon dioxide (CO2) supercritical condition to obtain the supercritical extract; glauber salt is taken, heated and dissolved in the water to be filtered, the filtered liquid is mixed with the rhubarb extract, the desmodium-honeysuckle extract and the supercritical extract as well as dextrine and 70% ethanol to be made into granules, the granules are dried, carried out tabletting, and coated with a membrane. The cholagogic tablet which is prepared through the above method is convenient to take.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a preparation method of traditional Chinese medicine. Background technique [0002] Lidan tablets are composed of 11 herbs including rhubarb, honeysuckle, money grass, woody fragrance, Anemarrhena, Folium Folium, Bupleurum, Radix Paeoniae Alba, Scutellaria baicalensis, Glauber's salt, and capillary, recorded in the 2010 edition of Pharmacopoeia of the People's Republic of China One part can soothe the liver and relieve pain, clear away heat and dampness. It is used for hypochondriac pain caused by liver and gallbladder damp-heat. Symptoms include hypochondriac pain and stomach pain, severe pressure pain, constipation, short red urine, fever and headache, vomiting and inability to eat; biliary tract disease sees the above syndromes. [0003] [0004] In the prior art, there is no report on the use of Lidan tablets in the treatment of dysmenorrhea. [0005] In the prior art, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K9/28A61P1/16A61K33/04
Inventor 王峰王琳张发成
Owner JIANGSU KANGHENG CHEM
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