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Method for extracting rhoifolin from turpinia formosana leaves

A kind of technology of Shanxiang round leaves and rhubaricin, applied in the field of natural medicinal chemistry, can solve the problems of excessive waste liquid generation, difficult purification, and extraction of impurities, and achieve the effects of short time, less reagent consumption, and high extraction efficiency

Inactive Publication Date: 2012-03-28
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing extraction and separation of Rhododendron uses hot water extraction, which has many impurities in the extraction, difficult purification, cumbersome process, high energy consumption, and more waste liquid, which is a high-pollution and high-energy-consumption method

Method used

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  • Method for extracting rhoifolin from turpinia formosana leaves

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Experimental program
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Embodiment 1

[0015] The raw material of Shanxiang round leaves is crushed to 40 meshes, 2kg is added to the supercritical extraction kettle, and liquid CO2 is introduced, and the extraction pressure is 20MPa, and the temperature is 40°C. After the above parameters are reached, the flow rate of liquid CO2 is adjusted to 20kg / h, and the entrained Reagent 50% ethanol solution, flow rate 2L / h, dynamic extraction for 2 hours, analyze the extract under pressure 6MPa, temperature 60 ℃ adjustment, recover reagent, the obtained extract is dissolved in hot water, add 2% activated carbon activated carbon for decolorization, decolorization solution Filter out the activated carbon, add the liquid to 200ml polyamide resin for adsorption, first take 4BV of 30% ethanol solution to elute the impurities, then use 3BV of 50% ethanol solution to elute the target components, collect the target components and concentrate under reduced pressure, the concentrated liquid crystallizes, The crystals were filtered out...

Embodiment 2

[0017] The raw material of Shanxiang round leaves is crushed to 80 meshes, 2kg is added to the supercritical extraction kettle, and liquid CO2 is introduced, and the extraction pressure is 20MPa, and the temperature is 50°C. After the above parameters are reached, the flow rate of liquid CO2 is adjusted to 25kg / h, and the entrained 70% ethanol solution, flow rate 2L / h, dynamic extraction for 2 hours, analyze the extract at a pressure of 9MPa and a temperature of 50°C, recover the reagent, dissolve the obtained extract in hot water, add 1% activated carbon for decolorization, and decolorize the decolorization solution Filter out the activated carbon, add the liquid to 200ml polyamide resin for adsorption, first take 6BV of 20% ethanol solution to elute impurities, then use 5BV of 40% ethanol solution to elute the target components, collect the target components and concentrate under reduced pressure, the concentrated liquid crystallizes, The crystals were filtered out, dissolved...

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Abstract

The invention discloses a method for extracting rhoifolin from turpinia formosana leaves. The method comprises the following steps of: crushing the turpinia formosana leaves serving as a raw material into 40 to 80 meshes, adding the powder into a supercritical extraction kettle, introducing liquid CO2 and entrainer, extracting for 2 to 3 hours under the pressure of 20 to 30MPa and at the temperature of between 40 and 50 DEG C, regularly resolving the extract, reclaiming the reagent, dissolving the obtained extract into hot water, adding active carbon for decolorization, adding polyamide resin for adsorption into the decolorized solution, performing gradient elution by using an aqueous solution of ethanol, collecting the target component, concentrating under reduced pressure, crystallizing the concentrate, filtering the crystal, dissolving the crystal into the hot water, performing re-crystallization, drying, and thus obtaining the rhoifolin. The method for producing the rhoifolin is low in energy consumption, low in pollution, simple in steps and high in purity of the obtained product, and is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to a method for extracting rhubaricin from the round leaves of syringa japonica. Background technique [0002] Rhoifolin, CAS: 17306-46-6, molecular formula: C 27 h 30 o 14 , molecular weight: 578.53 structural formula: [0003] [0004] Rhodoglutin is a flavonoid substance, light yellow powder, melting point mp.257-258°C, has anti-tumor, antihypertensive and anti-xanthine oxidase and anti-oxidation effects. [0005] Shanxiang round leaves are Shengguyouke Shanxiangyuan Turpinia arguta Dry leaves of Seem. It is also called two-finger sword, thousand hammer, seven-inch nail, thousand hammer, big bone, and little bear bile wood. It has the effects of clearing away heat and detoxification, relieving throat and reducing swelling. According to the Pharmacopoeia 2010, the content of rhubaricin in the leaves of Shanxiang round leaves should not be less than...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCY02P20/54
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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