Application of pseudojujubogenin to preparation of medicaments for resisting senile dementia

A technology of jujuberenin and senile dementia, which is applied in the direction of drug combination, pharmaceutical formula, steroidal compounds, etc., can solve the problems of undeveloped drugs, etc., and achieve the effect of great clinical application value

Inactive Publication Date: 2012-03-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, no form of medicine has

Method used

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  • Application of pseudojujubogenin to preparation of medicaments for resisting senile dementia
  • Application of pseudojujubogenin to preparation of medicaments for resisting senile dementia
  • Application of pseudojujubogenin to preparation of medicaments for resisting senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The pseudo-jujuboside prepared in Example 1 was used in the following experiments.

Embodiment 2

[0040] Example 2 Observation of the effect of pseudo-jujuboside on the acquisition of memory impairment

[0041] This experiment observes the influence of pseudo-jujuboside on the acquisition of memory impairment. Scopolamine is an M-choline receptor blocker. It can block the agonistic effect of acetylcholine on M-receptors, block the transmission of acetylcholine in the cerebral cortex and hippocampus, inhibit the formation of conditioned reflexes, and affect learning and memory. Functional activity. After the mice have matured in training, given the appropriate amount of the test drug before the last day of training, and appropriate administration of scopolamine can block the memory acquisition process of the mice, so as to observe the effect of the test drug on the memory acquisition. Morris water maze method can be used to detect the effect of drugs on the learning and memory of model mice.

[0042] 2. Experimental materials

[0043] Experimental animal

[0044] Strain: ICR mou...

Embodiment 3

[0106] Example 3 Protective effect of pseudo-jujuboside on animals with focal cerebral ischemia-reperfusion injury

[0107] Experimental principle

[0108] The right common cerebral artery (CCA), external carotid artery (ECA) and its branch arteries and the right internal carotid artery (ICA) were blocked by suture method in rats. Reperfusion after blocking for 2 hours can cause local brain tissue Ischemia damage, especially damage to the hippocampus and cerebral cortex CA1 of the rat brain, can well mimic the symptoms of vascular dementia.

[0109] 2. Experimental materials

[0110] Experimental animal

[0111] Strain: Sprague-Dawley rats

[0112] Sex: male

[0113] Weight: 250~300g

[0114] Source: Shanghai Sipuer-Bikai Laboratory Animal Co., Ltd.

[0115] Animal certificate number: SCXK (Shanghai) 2008-0016

[0116] Test drug

[0117] Name: Pseudo-jujuboside

[0118] Source: prepared in Example 1

[0119] Properties: white powder, soluble in water

[0120] In this experiment, three pre-reage...

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Abstract

The invention provides application of pseudojujubogenin to preparation of medicaments for resisting senile dementia. The pseudojujubogenin is shown as a structural formula. Through research on influence of the pseudojujubogenin on mouse memory acquisition impairment caused by scopolamine, the memory acquisition impairment can be improved when the pseudojujubogenin is orally taken by a mouse in ratios of 150 mg/kg, 50 mg/kg, and 15 mg/kg; a mouse suffering from focal cerebral ischemic-reperfusion injury can be protected when the pseudojujubogenin is taken by the mouse in ratios of 35 mg/kg, 15mg/kg, and 5 mg/kg; and memory impairment of APP/PS1 double transgenic mice can be obviously improved when the pseudojujubogenin is taken by the mouse in ratios of 50 mg/kg and 15mg/kg. Therefore, the pseudojujubogenin can be used for preparing the medicaments for resisting the senile dementia and has great clinical application value.

Description

Technical field [0001] The invention relates to medicines, in particular to the application of the preparation of new triterpenoids from Bacopa oleracea extracts in the preparation of anti-senile dementia medicines, and in particular to the application of pseudosaccharin in the preparation of anti-senile dementia medicines. Background technique [0002] Alzheimer's disease is a group of syndromes with a lack of cognitive function as its core symptom. It is a chronic progressive neurodegenerative disease and the most common mental disease that endangers human health. Among them, Alzheimer’s disease (AD) is the most common. According to incomplete statistics, the world population of dementia patients will reach 3 million by 2020. According to the latest scientific research report of the United States in 2011, China, as a country that is about to enter an aging country, has an explosion in the number of dementia patients. And the age of dementia patients is getting younger and youn...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P25/28C07J71/00
Inventor 刘晓军单磊苏娟张卫东沈云亨柳润辉李慧梁徐希科
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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