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Externally applied medicine for treating gout and preparation method thereof

A technology for external application of medicine and gout, which is applied in the field of external application of medicine for the treatment of gout and its preparation, and can solve the problems of ineffectiveness, unsatisfactory treatment effect, destruction of active ingredients and the like

Inactive Publication Date: 2012-03-14
莫寿科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this method has the following disadvantages: 1. Since the cooking time, temperature and pressure cannot be unified, it is difficult to extract the active ingredients in the Chinese medicinal materials; Sensitive active ingredients; 3. Most of the traditional Chinese medicine ingredients extracted through simple boiling and leaching are intermediates of active ingredients, which must be transformed by probiotics in the human body, and finally become active active ingredients that enter the blood. Due to the different status of probiotics in the human body , resulting in slow or ineffective effects, etc., and the treatment effect is unsatisfactory. It is an important task for the prevention and treatment of gout to develop non-toxic and efficient new anti-gout drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method for an external application medicine for the treatment of gout, comprising the steps of:

[0036] (1) Crush the Chinese herbal medicine Sunflower, buckwheat root, Qianjinba, Yiduoyun, and Aescin into 100 meshes, autoclave for 30 minutes, and set aside;

[0037] (2) Boil the rice vinegar over a warm fire, let it cool down to room temperature naturally, and set aside;

[0038] (3) Soak the five kinds of Chinese herbal medicines described in step (1) respectively in the rice vinegar sterilized in step (2), and the ratio of solid to liquid is 1: (8-10);

[0039] (4) After acetobacter GLYSM66 was expanded and cultured with LB medium, it was inoculated into each medicinal material soaking solution, and the inoculation amount was: medicinal material soaking solution:bacteria volume ratio = (20-50) : 1;

[0040] (5) Fermentation is carried out at room temperature. The fermentation time of each single medicinal material is: sunflower 150 days; buckwheat roo...

Embodiment 2

[0044] Carry out according to the method steps of Example 1, the difference is: the weight ratio (kg) of blending the fermentation liquid of each drug described in step (6) is: sunflower: buckwheat root: jackfruit: a cloud: aescin =0.8︰2.5︰1.5︰0.6︰0.4, sealed for 110 days after blending.

Embodiment 3

[0046] Example of using this external application to treat leg gout:

[0047] 1. Patient: Qin, male, 45 years old, from Pingle County, Guilin City, Guangxi, had gout for many years, the symptoms before treatment: uric acid was as high as 745 μmol / L, and both feet could not touch the ground when the pain occurred. After three days of treatment with this drug , can walk down the ground slightly, recovered after two courses of medication, uric acid basically returned to the normal value, and no recurrence has been seen so far. The treatment effect is shown in Table 1.

[0048] Table 1: Routine detection of uric acid in blood

[0049] before and after medication test result Reference value (μmol / L) check hospital check the time Before medication 745 124-416 Pingle County People's Hospital 2011.04.24 after medication 488 87-418 Guilin Boai Hospital 2011.05.19 after medication 436 124-416 Pingle County People's Hospital 2011.05.27 ...

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PUM

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Abstract

The invention provides an externally applied medicine for treating gout and a preparation method thereof. The preparation method comprises the following steps: respectively soaking sunflower, buckwheat root, Philippine flemingia root, Pittosporum glabratum Lindl and Paris polyphylla in boiled rice vinegar; inoculating Acetobacter sp. GLYSM66 CCTCC NO:M2011238, and fermenting for different fermentation times; and blending the fermentation liquids to obtain the externally applied medicine for treating gout. The externally applied medicine has the functions of dredging the channels and quickly lowering the uric acid level in the blood of a patient with gout, and has the advantages of quick pain alleviating, good curative effect, low cost, no toxic or side effect and simple preparation method.

Description

technical field [0001] The invention relates to a medicine for external application, in particular to a medicine for external application for treating gout and a preparation method thereof. Background technique [0002] Gout, also known as "hyperuricemia", is a disorder of purine metabolism and belongs to arthritis. Gout is the disorder of the metabolism of purine substances in the body, the synthesis of uric acid increases or the excretion decreases, resulting in hyperuricemia. When the blood uric acid concentration is too high, uric acid is deposited in the joints, cartilage and kidneys in the form of sodium salt, causing tissue damage. Foreign body inflammatory reaction, that is, gout, the general attack part is the thumb joint, ankle joint, knee joint and so on. Redness, swelling, heat, and severe pain appear at the site of an acute gout attack, usually in the middle of the night, which can wake people up from sleep. In the early stage of gout, the attack is more common...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/70A61P19/06
Inventor 莫寿科
Owner 莫寿科
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