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Compound triamcinolone acetate-urea cream and preparation method thereof

A technology of triamcinolone and acetic acid, which is applied in the field of compound triamcinolone acetate urea cream and its preparation, and can solve problems such as affecting the appearance, easily killing white blood cells, liver and kidney damage, etc.

Inactive Publication Date: 2012-03-14
JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it is not life-threatening, it will not be cured for a long time, and the recurrence will be aggravated year by year, desquamation and blood addiction, dryness and itching are unbearable, which brings great pain to the patient's physical and mental health, and seriously affects the quality of life
Especially boys and girls, the skin is ashamed to be exposed, which directly affects the appearance, and has a great negative impact on study, work, and making friends
There are many drugs for the treatment of psoriasis, but the general cure rate is not ideal, and the side effects are large. Due to its mechanism, it is easy to kill white blood cells and damage the liver and kidney.

Method used

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Embodiment 1

[0015] Among the present invention, described a kind of compound triamcinolone acetate urea emulsifiable cream and preparation method thereof comprise the steps:

[0016] ① Weigh the crude drug triamcinolone acetate and urea in the stated weight percentage, fully mix, and set aside;

[0017] ② Weigh the emulsion base in the stated weight percentage, put glyceryl monostearate, beeswax, paraffin, and stearic acid in an evaporating dish, heat and melt on a water bath, then add white vaseline, liquid paraffin, aluminum distearate , heated to 60-80°C. In addition, dissolve calcium hydroxide and ethylparaben in distilled water and heat to 60-80°C, add to the above oil phase solution, and keep stirring in the same direction while adding until it becomes a milky white semi-solid.

[0018] ③ Add the uniformly mixed raw material drug into the emulsion-type base ointment, and then mix and stir to form an ointment.

[0019] cases.

[0020] Li, male, 40 years old, had psoriasis from a s...

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PUM

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Abstract

The invention discloses compound triamcinolone acetate urea-cream and a preparation method thereof, relating to the technical field of medicine. The compound triamcinolone acetate-urea cream consists of triamcinolone acetate, urea and an emulsion substrate. In the compound triamcinolone acetate-urea cream, triamcinolone acetate serves as a medium-efficiency glucocorticoid which can be used for eliminating fever, flushing and swelling caused by local non-infectious inflammation; and urea has the effects of dissolving and denaturalizing keratoprotein and enhancing the cuticle layer hydration, so that skin is softened, and cracking is prevented. The compound triamcinolone acetate urea-cream has the effects of suppressing movement of inflammatory cells to inflammatory positions, preventing inflammatory media from being released, stability a lysosome membrane, suppressing immune reactions and improving the stress ability of a mechanism to noxious stimulus.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound triamcinolone acetate urea cream and a preparation method thereof. Background technique [0002] Psoriasis, also known as psoriasis, is a common chronic inflammatory skin disease with intractable and relapsing characteristics. An important feature of the pathophysiology of psoriasis is that the keratin cells of the basal layer enter the proliferation pool significantly more than normal, and the cell proliferation accelerates, and the mitotic cycle is shortened from the normal 311 hours to 37.5 hours. The passage time of the epidermis is also shortened from 28-56 days to 3-4 days. Because the keratin cells pass through the epidermis too quickly, it is too late to fully mature, and parakeratosis appears histologically, and the granular layer disappears. The skin lesions are characterized by erythematous papules at the beginning, the epidermis is covered with layers of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/17A61K9/06A61P17/06
Inventor 刘德胜
Owner JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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