Application of 3,3'-diindolylmethane and 3,3'-diindolylmethane derivatives in preparation of drugs for treating liver diseases

Abstract

This invention relates to biopharmaceutical technology, specifically to the application of 3,3'-Diindolylmethane, indole-3-carbinol, and derivatives thereof in the preparation of drugs for treating such hepatic diseases as viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, fatty liver, hepatic fibrosis and hepatic cirrhosis. The said indole-3-carbinol, diindolylmethane and derivatives thereof can effectively protect the human body from the damage resulting from ROS by inhibiting ROS-induced activation of hepatic stellate cells and correlated expression of collagen, which consequently ameliorates degree of hepatic fibrosis. Therefore they can be used in treatment of diseases related to hepatic fibrosis. As is verified in the animal models of hepatic fibrosis, the said indole-3-carbinol, diindolylmethane and derivatives thereof present excellent therapeutic effect and positive application prospect.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, in particular to 3,3'-diindolylmethane (DIM) and its precursor compound indole-3-carbinol (I3C) and their derivative compounds in the preparation and treatment of liver fibrosis and hepatitis , a drug for cirrhosis-associated liver disease. 2. Background technology [0002] Liver fibrosis refers to the excessive deposition of diffuse extracellular matrix (especially collagen) in the liver. It is not an independent disease. Many chronic liver diseases can cause liver fibrosis. The etiology can be roughly divided into infectious (chronic B, C and D viral hepatitis, schistosomiasis, etc.), congenital metabolic defects ( Hepatolenticular degeneration, hemochromatosis, α1-antitrypsin deficiency, etc.), chemical metabolic defects (chronic alcoholic liver disease, chronic drug-induced liver disease) and autoimmune hepatitis, primary biliary cirrhosis and primary Sclerosing cholangitis, etc. It...

AI Technical Summary

Problems solved by technology

Although 3,3'-diindolylmethane has been reported in the literature that it can protect the body from free radical damage, there is no report on its use in the treatment of liver fibrosis and related hepatitis and cirrhosis

Images