Integrated microfluidic chip for capture of cancer cells in whole blood
A technology of microfluidic chips and cancer cells, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low selectivity and easy fracture of PDMS, and achieve the effects of simple manufacturing process, avoiding pollution, and reducing flow resistance
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[0039] like figure 1 As shown, an integrated microfluidic chip for whole blood cancer cell capture is mainly composed of inlet 1, red blood cell lysing unit 2, white blood cell capture unit 3, cancer cell capture unit 4 and outlet 5.
[0040] There are three inlets 1, which are whole blood inlet, erythrocyte lysate inlet and buffer solution inlet containing leukocyte surface antigen antibody magnetic beads respectively.
[0041] like figure 2 As shown, the inlet 1 is a cylindrical cavity structure in PDMS with a diameter of 1.5mm and a height of 3mm.
[0042] The middle inlet of the inlet 1 is 4 mm long, 100 μm wide, and 20 μm high, and the pipes on both sides are 3 mm long, 100 μm wide, and 20 μm high.
[0043] The erythrocyte lysing unit 2 is an S-shaped mixing channel structure.
[0044] like image 3 As shown, the S-shaped mixing channel is composed of a plurality of semicircular rings connected end to end, and the radius of the inner semicircle is R 1 150μm, outer s...
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