Method for chemical synthesis of vitamin K2

Abstract

The invention relates to a method for chemical synthesis of vitamin K2, and belongs to the technical field of organic synthesis. In the method, 2-methyl-1,4-naphthoquinone and geraniol are taken as raw materials, catalytic hydrogenation is firstly performed on 2-methyl-1,4-naphthoquinone for reducing 2-methyl-1,4-naphthoquinone into 2-methyl-1,4-hydronaphthoquinone, then Fridel-Crafts alkylation reaction is further performed with geraniol, and the product is finally obtained by oxidation reaction. The method has the characteristics of high product yield, high recycling rate of materials, low production cost, simplicity and convenience in production process and low energy consumption, and is conductive to environmental protection, convenient to popularize and apply and the like. The method can be widely used for industrialized large-scale production of vitamin K2, and vitamin K2 product synthesized by adopting the method can be widely used as the raw material for medicines, health-care products and the like.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, in particular to a chemically synthesized vitamin K 2 Methods. Background technique [0002] Vitamin K 2 It is a general term for a series of 2-methyl-1,4-naphthoquinone derivatives with biological activity of phylloquinone, and it is one of the indispensable important vitamins in the human body. Vitamin K 2 It can prevent liver cirrhosis from progressing to liver cancer. It is used to treat vitamin K deficiency hemorrhage, promote the formation of prothrombin, accelerate blood coagulation, and treat osteoporosis. It also has functions such as diuresis, strengthening the detoxification function of the liver, and lowering blood pressure. Great medical value. Therefore, synthetic vitamin K 2 become a major research topic. [0003] Existing chemically synthesized vitamin K 2 methods, such as the patent application number 20071006604.4 "a vitamin K 2 In the "synthetic method of a se...

AI Technical Summary

Problems solved by technology

[0004] 1. What the reaction that 2-methyl-1,4-naphthoquinone is reduced into hydroquinone of this method adopts is common reducing agent reducing method, needs to use reducing agent KBH in a large amount 4 , the follow-up separation is difficult, the corresponding energy consumption is large, and the production cost is high

[0005] 2. The Fridel-Crafts alkylation reaction itself of this method is the process of constantly generating water, and the catalyst anhydrous zinc chloride, boron trifluoride ether, and cuprous bromide are sensitive to water and easily decompose in water. It will inevitably lead to the deactivation of part of the catalyst, resulting in waste of the catalyst, which in turn affects the yield of this step reaction, which is not good for production

Because the catalyst is sensitive to water, the entire system must maintain a strict anhydrous environment for the Fridel-Crafts alkylation reaction to occur, which requires high equipment and will increase production costs

[0006] 3. The Fridel-Crafts alkylation reaction of this method does not process or recycle the solvent nitromethane and catalyst used, resulting in waste of resources and environmental pollution

[0007] 4. The post-treatment of the crude product of this method adopts column chromatography, the investment of related equipment is large, the consumption of eluent and adsorbent is large, and the recovery of eluent is difficult, the energy consumption is large, and the production cost is increased

[0008] 5. The total product yield of this method is not high, the highest is only 50.1%, which is not conducive to industrial scale production